In this paper, we study the emergy evaluation index system of the sustainable development of Shenyang Economic and Technological Development Zone (SETDZ) by system dynamics model, and employ the simulation of dynamic evaluation analysis. By the simulation of system dynamics model, four SETDZ’s development scenarios are designed, including inertia scenario, economic scenario, environmental protection scenario and science and technology scenario, and the sustainable development status of each scenario is simulated and dynamically evaluated. The results show that under the background of coordinated development of economy and environment, science and technology scenario based on high-tech investment is the most dynamic, and it also is the best development strategy of SETDZ. Furthermore, SETDZ could achieve the coordinated development of economy and environment by reasonable layout of industrial enterprises, integration of public resources, effective utilization and disposal of waste, establishment of enterprise symbiosis system, development of cleaner production and other measures.