Competing interests
Lauren E Kelly holds funding from the Canadian Institutes of Health Research as the director for the IMPaCT Clinical Trials Training Platform and from Research Manitoba which funded this work. Salaheddin M Mahmud has received unrestricted research grants from GlaxoSmithKline, Merck, Pfizer, Sanofi Pasteur and Roche-Assurex. Salaheddin M Mahmud has received fees as a consultant and advisory board member for GlaxoSmithKline, Merck, Sanofi Pasteur and Seqirus. The remaining authors declare that they have no competing interests.
Author’s contributions
Mohamed Ben-Eltriki: Concept, Methodology, Supervision, Data Collection and Analysis, Writing- Original draft preparation, and Finalized the Manuscript.
Manik Chhabra: Data Collection and Analysis, Writing- Reviewing and Editing.
Aisha Rafiq: Data Collection and Analysis, Writing- Reviewing and Editing.
Michael O.S. Afolabi: Concept, Reviewing and Editing.
Arun Paul: Data Collection and Analysis, Writing- Reviewing and Editing.
Devashree Prabhu: Data Collection and Analysis, Reviewing and Editing.
Christine J Neilson: Designed, Edited and Conducted the Literature search.
Robert Bashaw: Concept, Reviewing and Editing.
Salaheddin M Mahmud: Concept, Reviewing and Editing.
Thierry Lacaze-Masmonteil: Concept, Reviewing and Editing.
Susan Marlin: Concept, Reviewing and Editing.
Martin Offringa: Concept, Reviewing and Editing.
Nancy J. Butcher: Concept, Reviewing and Editing
Anna Heath: Concept, Reviewing and Editing.
Michelle Driedger: Concept, Reviewing and Editing.
Lauren E Kelly: Conceptualization, Established the Project Team/Funding, Methodology, Supervision, Reviewing and Editing, Finalized the Manuscript.
Author’s information
Mohamed Ben-Eltriki, RPh, MSc, Ph.D., Postdoctoral Clinical Researcher, Department of Pharmacology and Therapeutics, Max Rady College of Medicine, University of Manitoba, MB, Canada, Systematic Reviewer, Cochrane Hypertension Review Group, Therapeutic Initiative, University of British Columbia, Vancouver, BC, Canada, Community Pharmacist, Vancouver, BC, Canada.
Manik Chhabra: PharmD, Ph.D. candidate, Department of Pharmacology and Therapeutics, Max Rady College of Medicine, University of Manitoba, Canada.
Aisha Rafiq, MD, Research Assistant, Department of Pharmacology and Therapeutics, Max Rady College of Medicine, University of Manitoba, Canada.
Michael O.S. Afolabi, PhD, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba.
Arun Paul, PharmD, MSc, Research Assistant, Department of Pharmacology and Therapeutics, Max Rady College of Medicine, University of Manitoba, Canada.
Devashree Prabhu, Research Coordinator, Knowledge Synthesis and Knowledge Translation, George and Fay Yee Centre for Healthcare Innovation, Winnipeg, MB, Canada.
Robert Bashaw, MSc, Ph.D., Senior biostatistician, Department of Community Health Sciences, University of Manitoba, Data Science Platform, George and Fay Yee Centre for Healthcare Innovation, Winnipeg, MB, Canada.
Salaheddin M Mahmud, MD, Ph.D., FRCPC, Professor, Max Rady College of Medicine, Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Christine J Neilson, MLIS Health Sciences Librarian, Neil John Maclean Health Sciences Library, University of Manitoba, Winnipeg, MB, Canada.
Thierry Lacaze-Masmonteil, MD, Ph.D., FRCPC, Clinical Professor of Pediatrics, Cumming School of Medicine, University of Calgary, Alberta, Canada.
Susan Marlin, MSc, Clinical Trialist, President and CEO of Clinical Trials Ontario, Ontario, Canada.
Martin Offringa, MD, Ph.D., Professor, Department of Paediatrics, Institute of Health Policy, Management & Evaluation, University of Toronto, Senior Scientist, Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada.
Nancy J. Butcher, Ph.D., Assistant Professor, Department of Psychiatry at the University of Toronto, Methodologist, The Hospital for Sick Children, Toronto, Ontario, Canada.
Anna Heath, MMath, Ph.D., Assistant Professor, Division of Biostatistics, Dalla Lana School of Public Health, Scientist, Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada. Honorary Research Fellow, Department of Statistical Science, University College London, London, UK.
Michelle Driedger, BA, MA, PhD, Professor, Max Rady College of Medicine, Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Lauren E Kelly, PhD, MSc, BMedSci, CCRP, Assistant Professor, Departments of Pharmacology and Therapeutics, Community Health Sciences, University of Manitoba, Clinical Trials Director and Scientist, Children's Hospital Research Institute of Manitoba, George & Fay Yee Centre for Healthcare Innovation, Winnipeg, MB, Scientific Director, the Canadian Collaborative for Childhood Cannabinoid Therapeutics (C4T) (www.medcankids.ca)
Author details
1Department of Pharmacology and Therapeutics, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
2Clinical Research and Methods, George and Fay Yee Centre for Healthcare Innovation, Winnipeg, MB, Canada.
3Cochrane Hypertension Review Group, Therapeutic Initiative, University of British Columbia, Vancouver, BC, Canada.
4Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
5Department of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
6Neil John Maclean Health Sciences Library, University of Manitoba, Winnipeg, MB, Canada.
7Department of Pediatrics, Cumming School of Medicine, University of Calgary, Alberta, Canada.
8Clinical Trials Ontario, Toronto, Ontario, Canada.
9Children’s Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.
10Department of Paediatrics, Institute of Health Policy, Management & Evaluation, University of Toronto, Ontario, Canada.
11The Hospital for Sick Children, Toronto, Ontario, Canada.
12Department of Psychiatry at the University of Toronto, Toronto, Ontario, Canada.
13Division of Biostatistics, Dalla Lana School of Public Health, Scientist, Child Health Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada.
14Department of Statistical Science, University College London, London, UK
Ethics approval: Not applicable
Consent for publication: Not applicable
Availability of data and materials: Not applicable
Acknowledgments: None.
Funding: This work was funded by a New Investigator Operating Grant (Kelly) from Research Manitoba. Anna Heath is supported by a Canada Research Chair in Statistical Trial Design and funded by the Discovery Grant Program of the Natural Sciences and Engineering Research Council of Canada (RGPIN-2021-03366).