1 WHO. Global report on diabetes. (2016).
2 Lamers, M. L., Almeida, M. E., Vicente-Manzanares, M., Horwitz, A. F. & Santos, M. F. High glucose-mediated oxidative stress impairs cell migration. PLoS One 6, e22865, doi:10.1371/journal.pone.0022865 (2011).
3 Yach, D., Stuckler, D. & Brownell, K. D. Epidemiologic and economic consequences of the global epidemics of obesity and diabetes. Nat. Med. 12, 62–67 (2006).
4 Randeria, P. S. et al. siRNA-based spherical nucleic acids reverse impaired wound healing in diabetic mice by ganglioside GM3 synthase knockdown. Proc. Natl. Acad. Sci. USA 112, 5573–5578, doi:10.1073/pnas.1505951112 (2015).
5 Ram, M. et al. Bilirubin modulated cytokines, growth factors and angiogenesis to improve cutaneous wound healing process in diabetic rats. Int Immunopharmacol 30, 137-149, doi:10.1016/j.intimp.2015.11.037 (2016).
6 Li, J., Zhang, Y. P. & Kirsner, R. S. Angiogenesis in wound repair: angiogenic growth factors and the extracellular matrix. Microsc Res Tech 60, 107-114, doi:10.1002/jemt.10249 (2003).
7 Soneja, A., Drews, M. & Malinski, T. Role of nitric oxide, nitroxidative and oxidative stress in wound healing. Pharmacol. Rep. 57 (suppl.), 108–119 (2005).
8 Blakytny, R., Jude, E. B., Gibson, J. M., Boulton, A. J. M. & Ferguson, M. W. J. Lack of insulin-like growth factor 1 (IGF1) in the basal keratinocyte layer of diabetic skin and diabetic foot ulcers. J. Pathol. 190, 589–594 (2000).
9 Wu, Y. C., Zhu, M. & Robertson, D. M. Novel nuclear localization and potential function of insulin-like growth factor-1 receptor/insulin receptor hybrid in corneal epithelial cells. PLoS One 7, e42483, doi:10.1371/journal.pone.0042483 (2012).
10 Jung, H. J. & Suh, Y. Regulation of IGF -1 signaling by microRNAs. Front. Genet. 5, 1–13, doi:10.3389/fgene.2014.00472 (2015).
11 Nagano, T. et al. Effects of substance P and IGF-1 in corneal epithelial barrier function and wound healing in a rat model of neurotrophic keratopathy. Invest. Ophthalmol. Vis. Sci. 44, 3810–3815, doi:10.1167/iovs.03-0189 (2003).
12 Stuard, W. L., Titone, R. & Robertson, D. M. The IGF/insulin-IGFBP axis in corneal development, wound healing, and disease. Front. Endocrinol. (Lausanne) 11, 1–15, doi:10.3389/fendo.2020.00024 (2020).
13 Blakytny, R., Jude, E. B., Gibson, J. M., Boulton, A. J. M. & Ferguson, M. W. J. Lack of insulin-like growth factor 1 (IGF1) in the basal keratinocyte layer of diabetic skin and diabetic foot ulcers. J Pathol. 190, 589-594 (2000).
14 Guler, H. P., Zapf, J., Schmid, C. & Froesch, E. R. Insulin-like growth factors I and II in healthy man. estimations of half-lives and production rates. Acta Endocrinol. 121, 753–758 (1989).
15 Demling, R. H. The Role of Anabolic Hormones for Wound Healing in Catabolic States. J. Burns Wounds 4, e2 (2005).
16 Zhao, Z., Li, Y. & Xie, M.-B. Silk fibroin-based nanoparticles for drug delivery. Int. J. Mol. Sci. 16, 4880–4903, doi:10.3390/ijms16034880 (2015).
17 Cao, Y. & Wang, B. Biodegradation of silk biomaterials. Int. J. Mol. Sci. 10, 1514–1524, doi:10.3390/ijms10041514 (2009).
18 Huang, W., Ling, S., Li, C., Omenetto, F. G. & Kaplan, D. L. Silkworm silk-based materials and devices generated using bio-nanotechnology. Chem. Soc. Rev. 47, 6486–6504, doi:10.1039/c8cs00187a (2018).
19 Inoue, S. et al. Silk fibroin of Bombyx mori is secreted, assembling a high molecular mass elementary unit consisting of H-chain, L-chain, and P25, with a 6:6:1 molar ratio. J. Biol. Chem. 275, 40517–40528, doi:10.1074/jbc.M006897200 (2000).
20 Shen, Y., Johnson, M. A. & Martin, D. C. Microstructural characterization of Bombyx mori silk fibers. Macromolecules 31, 8857–8864, doi:10.1021/ma980281j (1998).
21 Yucel, T., Lovett, M. L. & Kaplan, D. L. Silk-based biomaterials for sustained drug delivery. J. Control Release 190, 381-397, doi:10.1016/j.jconrel.2014.05.059 (2014).
22 Farokhi, M., Mottaghitalab, F., Fatahi, Y., Khademhosseini, A. & Kaplan, D. L. Overview of silk fibroinuse in wound dressings. Trends Biotechnol. 36, 907–922, doi:10.1016/j.tibtech.2018.04.004 (2018).
23 Tran, S. H., Wilson, C. G. & Seib, F. P. A review of the emerging role of silk for the treatment of the eye. Pharm. Res. 35, 1–16, doi:10.1007/s11095-018-2534-y (2018).
24 Padol, A. R. et al. Efficacy of the silk protein based biofilms as a novel wound healing agent. Int. J. Toxicol. Appl. Pharm. 2, 31–36 (2012).
25 Shan, Y. H. et al. Silk fibroin/gelatin electrospun nanofibrous dressing functionalized with astragaloside IV induces healing and anti-scar effects on burn wound. Int. J. Pharm. 479, 291–301, doi:10.1016/j.ijpharm.2014.12.067 (2015).
26 Gil, E. S., Panilaitis, B., Bellas, E. & Kaplan, D. L. Functionalized silk biomaterials for wound healing. Adv. Healthc. Mater. 2, 206–217, doi:10.1002/adhm.201200192 (2013).
27 Lawrence, B. D., Marchant, J. K., Pindrus, M. A., Omenetto, F. G. & Kaplan, D. L. Silk film biomaterials for cornea tissue engineering. Biomaterials 30, 1299–1308, doi:10.1016/j.biomaterials.2008.11.018 (2009).
28 Gil, E. S. et al. Helicoidal multi-lamellar features of RGD-functionalized silk biomaterials for corneal tissue engineering. Biomaterials 31, 8953–8963, doi:10.1016/j.biomaterials.2010.08.017 (2010).
29 Liu, J. et al. Silk fibroin as a biomaterial substrate for corneal epithelial cell sheet generation. Invest. Ophthalmol. Vis. Sci. 53, 4130–4138, doi:10.1167/iovs.12-9876 (2012).
30 Kambe, Y., Kojima, K., Tamada, Y., Tomita, N. & Kameda, T. Silk fibroin sponges with cell growth-promoting activity induced by genetically fused basic fibroblast growth factor. J. Biomed. Mater. Res. A. 104, 82–93, doi:10.1002/jbm.a.35543 (2016).
31 Yodmuang, S. et al. Silk microfiber–reinforced silk hydrogel composites for functional cartilage tissue repair. Acta Biomater. 11, 27–36, doi:10.1016/j.actbio.2014.09.032 (2015).
32 Min, B. M. et al. Electrospinning of silk fibroin nanofibers and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro. Biomaterials 25, 1289–1297, doi:10.1016/j.biomaterials.2003.08.045 (2004).
33 Schneider, A., Wang, X. Y., Kaplan, D. L., Garlick, J. A. & Egles, C. Biofunctionalized electrospun silk mats as a topical bioactive dressing for accelerated wound healing. Acta Biomater. 5, 2570–2578, doi:10.1016/j.actbio.2008.12.013 (2009).
34 Wittmer, C. R. et al. Multifunctionalized electrospun silk fibers promote axon regeneration in central nervous system. Adv. Funct. Mater. 21, 4202, doi:10.1002/adfm.201190103 (2011).
35 Chopra, S. & Gulrajanii, M. L. Comparative evaluation of the various methods of degumming silk. Indian J. of Fibre Text. Res. 19, 76–83 (1994).
36 Khan, M. R. et al. Physical properties and dyeability of silk fibers degummed with citric acid. Bioresour. Technol. 101, 8439–8445, doi:10.1016/j.biortech.2010.05.100 (2010).
37 Cao, T. T., Wang, Y. J. & Zhang, Y. Q. Effect of strongly alkaline electrolyzed water on silk degumming and the physical properties of the fibroin fiber. PLoS One 8, e65654, doi:10.1371/journal.pone.0065654 (2013).
38 Aramwit, P., Damrongsakkul, S., Kanokpanont, S. & Srichana, T. Properties and antityrosinase activity of sericin from various extraction methods. Biotechnol. Appl. Biochem. 55, 91–98, doi:10.1042/ba20090186 (2010).
39 Kunz, R. I., Brancalhao, R. M., Ribeiro, L. F. & Natali, M. R. Silkworm sericin: properties and biomedical applications. Biomed. Res. Int. 2016, 8175701, doi:10.1155/2016/8175701 (2016).
40 Ohlsson, C. et al. The role of liver-derived insulin-like growth factor-I. Endocr. Rev. 30, 494–535, doi:10.1210/er.2009-0010 (2009).
41 Laron, Z. Insulin-like growth factor 1 (IGF-1): a growth hormone. Mol. Path. 54, 311–316 (2001).
42 Bright, G. M. Recombinant IGF-I: past, present and future. Growth Horm. IGF Res. 28, 62–65, doi:10.1016/j.ghir.2016.01.002 (2016).
43 Delafontaine, P., Song, Y. H. & Li, Y. Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler. Thromb. Vasc. Biol. 24, 435–444, doi:10.1161/01.ATV.0000105902.89459.09 (2004).
44 Ando, Y. & Jensen, P. J. Epidermal growth factor and insulin-like growth factor I enhance keratinocyte migration. J. Invest. Dermatol. 100, 633–639, doi:10.1111/1523-1747.ep12472297 (1993).
45 Haase, I., Evans, R., Pofahl, R. & Watt, F. M. Regulation of keratinocyte shape, migration and wound epithelialization by IGF-1- and EGF-dependent signalling pathways. J. Cell Sci. 116, 3227–3238, doi:10.1242/jcs.00610 (2003).
46 Sadagurski, M. et al. Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation. Mol. Cell. Biol. 26, 2675–2687, doi:10.1128/MCB.26.7.2675-2687.2006 (2006).
47 Wang, J., Zhou, J. & Bondy, C. A. Igf1 promotes longitudinal bone growth by insulin-like actions augmenting chondrocyte hypertrophy. The FASEB Journal 13, 1985–1990 (1999).
48 Achar, R. A. N., SilvaI, T. C., Achar, E., Martines, R. B. & Machado, J. L. M. Use of insulin-like growth factor in the healing of open wounds in diabetic and non-diabetic rats. Acta Cir. Bras. 29, 125–131 (2014).