Article
Spike-Directed Vaccination Elicits Robust Spike-Specific T cell Responses Including to Mutant Strains
https://doi.org/10.21203/rs.3.rs-403449/v1
This work is licensed under a CC BY 4.0 License
published 01 Sep, 2021
posted
You are reading this latest preprint version
While most studies describing COVID-19 vaccine responses have focused on antibodies, there is increasing evidence that T cells play a critical role. Here we evaluated T cell responses in seronegative donors before and after vaccination to define responses to SARS-CoV-2 reference strain, as well as to mutations in the variant strains B.1.1.7 and B.1.351. We observed enhanced T cell responses to reference and variant Spike strains post vaccination.
SARS-CoV-2
T cell responses to coronavirus
vaccination
COVID-19 variants
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Yes there is potential Competing Interest.
C.L., M.D.K., C.R.Y.C. and C.M.B. have intellectual property related to developing T cell therapies for infectious disease, including against SARS-CoV-2. All other authors declare no competing interests
Supplemental Table, Supplemental Figure Legends, Supplemental Figures
published 01 Sep, 2021
posted
You are reading this latest preprint version