This paper constructs an indicator system for the ecological security of water resources in the Yangtze River Basin using theories related to ecological population evolution and the DPSIR (Driving forces-Pressures-States-Impacts-Responses) model. It assesses the ecological security status of water resources in the provinces of the Yangtze River Basin from 2010 to 2019, identifies the development trends of ecological security of water resources in these provinces, and proposes corresponding strategies for regional ecological security and economic coordination development. According to the results of the ecological population evolution competition model, the overall ecological security indicators of water resources in the Yangtze River Basin have continuously improved, with safety levels increasing year by year. In the Yangtze River Basin, maintaining robust management of water resources is crucial for the sustainable development of the social economy. Based on this, with the aim of further promote the ecological safety of water resources in the Yangtze River Basin and the coordinated development of regional economy, this paper proposes policy recommendations such as promoting the continuous advancement of sustainable development projects, actively adjusting industrial structures, enhancing public environmental awareness continuously, and actively participating in international ecological construction to seek multi-sectoral cooperation.