Abdel-Diam MM, Samak DH, El-Sayed YS, Aleya L, Alarifi S, Alkahtani S (2019) Curcumin and quercetin synergistically attenuate subacute diazinon-induced inflammation and oxidative neurohepatic damage, and acetylcholinesterase inhibition in albino rats. Environ Sci Pollut Res Int 26:3659–3665.
Asiri YA. Probucol Attenuates Cyclophosphamide-induced Oxidative Apoptosis, p53 and Bax Signal Expression in Rat Cardiac Tissues. Oxid Med Cell Longev. 2010; 3: 308–316.
Al-Yahya, A.A., Al-Majed, A.A., Gado, A.M., Daba, M.H., Al-Shabanah, O.A., El-Azab,A.S., Abd-Allah, A.R.A., 2009. Acacia senegal gum exudate offers protection against cyclophosphamide-induced urinary bladder cytotoxicity. Oxid. Med.Cell. Longev. 2, 207–213.
Anderson D, Bishop JB, Garner RC, Ostrosky-Wegman P, Selby PB. Cyclophosphamide: review of its mutagenicity for an assessment of potential germ cell risks. Mutat Res. 1995 Aug; 330 (1-2):115-8.
Ludeman SM. The chemistry of the metabolites of cyclophosphamide. Curr Pharm Des. 1999; 5:627–644.
Bülbül, G. Y., Mİs, L., Șengül, E., Yıldırım, S., Çelebİ, F., & Çinar, A. (2018). Protective effects of Naringin on liver enzymes (AST, ALT, ALP) and histopathology in Cyclophosphamide-induced rats. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 13(2), 182-190.
Ren S., J.S. Yang, T.F. Kalhorn, J.T. Slattery, Oxidation of cyclophos-phamide to 4-hydroxycyclophosphamide and deschloroethylcy-clophosphamide in human liver microsomes, Cancer Res. 57 (19)(1997) 4229–4235.
J.P. Kehrer, S.S. Biswal, The molecular effects of acrolein, Toxicol. Sci.57 (1) (2000) 6–15.
Korkmaz, T. Topal, S. Oter, Pathophysiological aspects ofcyclophosphamide and ifosfamide induced hemorrhagic cystitis;implication of reactive oxygen and nitrogen species as well as PARPactivation, Cell Biol. Toxicol. 23 (5) (2007) 303–312).
Zhu H, Long MH, Wu J, Wang MM, Li XY, Shen H, Xu JD, Zhou L, Fang ZJ, Luo Y, Li SL. Ginseng alleviates cyclophosphamide-induced hepatotoxicity via reversing disordered homeostasis of glutathione and bile acid. Sci Rep. 2015 Dec 2; 5: 17536
L.B. Kenney, M.R. Laufer, F.D. Grant, H. Grier, L. Diller, High risk ofinfertility and long term gonadal damage in males treated with highdose cyclophosphamide for sarcoma during childhood, Cancer 91 (3)(2001) 613–621.
Ahmed LA, El-Maraghy SA, Rizk SM. Role of the KATP channel in the protective effect of nicorandil on cyclophosphamide-induced lung and testicular toxicity in rats. Sci Rep. 2015 Sep 25;5: 14043.
Şengül E, Gelen V, Gedikli S, Özkanlar S, Gür C, Çelebi F, Çınar A. The protective effect of quercetin on cyclophosphamide-Induced lung toxicity in rats. Biomed Pharmacother. 2017;92:303–307.
Dağ Y, Şengül E, Selçuk M, Yıldırım S, Çelebi F, Çınar DA. The Protective Effects of Naringin on Some Blood Paremeters and Kidney Histopathology in Cyclophosphamide Induced Nephrotoxicity in Rats. Atatürk Üniversitesi Vet Bil Derg, 2018;13, 219-228.
Rehman MU, Tahir M, Ali F, Qamar W, Lateef A, Khan R, Quaiyoom A, Oday-O-Hamiza, Sultana S. Cyclophosphamide-induced nephrotoxicity, genotoxicity and damage in kidney genomic DNA of Swiss albino mice: the protective effect of Ellagic acid. Mol Cell Biochem. 2012 Jun; 365(1-2):119-27.
Gunes S, Sahinturk V, Karasati P, Sahin IK, Ayhanci A. Cardioprotective Effect of Selenium Against Cyclophosphamide-Induced Cardiotoxicity in Rats. Biol Trace Elem Res, 2016, 1-8.
Morandi P, Ruffini PA, Benvenuto GM, Raimondi R, Fosser V: Cardiac toxicity of high dose chemotherapy. Bone Marrow Transplant 2005, 35:323-334.
Yeh ET, Tong AT, Lenihan DJ, Yusuf SW, Swafford J, Champion C, Durand JB, Gibbs H, Zafarmand AA, Ewer MS: Cardiovascular complication of cancer therapy: diagnosis, pathogenesis, and management. Circulation 2004, 109:3122–3131.
Slordal L, Spigset O: Heart failure induced by non-cardiac drugs. Drug Saf 2006, 29: 567–586.
Gelen V, and Şengül E. Antioxidant, antiinflammatory and antiapoptotic effects of Naringin on cardiac damage induced by cisplatin. Indian J. Tradit. Know. 2020, 19:2: 459- 465.
Gelen V, Şengül E, Gedikli S, Gür C, Özkanlar S (2017) Therapeutic effect of quercetin on renal function and tissue damage in the obesity induced rats. Biomed Pharmacother, 2017, 89:524–528.
Gelen V, Sengul E, Yildirim S, Atila G. The protective effects of naringin against 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats. Iran J Basic Med Sci, 2018, 21:404–410.
Goldberg MA, Antin JH, Guinan EC, Rappeport JM: Cyclophosphamide cardiotoxicity: an analysis of dosing as a risk factor. Blood 1986, 68: 1114–1118.)
Gibellini L, Pinti M, Nasi M, Montagna JP, De Biasi S, Roat E, Bertoncelli L, Cooper EL, Cossarizza A. Quercetin and cancer chemoprevention. Evid Based Complement Alternat Med. 2011; 2011: 591356.
Morales J, Günther G, Zanocco AL, Lemp E. Singlet oxygen reactions with flavonoids. A theoretical-experimental study. PLoS One. 2012; 7 (7): 40548.
Ertuğ PU, Aydinoglu F, Goruroglu Ozturk O, Singirik E, Ögülener N. Comparative study of the quercetin, ascorbic acid, glutathione and superoxide dismutase for nitric oxide protecting effects in mouse gastric fundus. Eur J Pharmacol. 2013 Jan 5; 698 (1-3): 379-87.
Gelen V, Şengül E, Gedikli S, Atila G, Uslu H, Makav M. The protective effect of rutin and quercetin on 5-FU-induced hepatotoxicity in rats Asian Pac. J. Trop. Biomed. 2017, 7:7 647-653
Gelen V, Sengul E, Yıldırım S, Celebi F, Cınar A (2018) Effects of rutin on bladder contractility and histopathology in cyclophosphamide-induced hemorrhagic cystitis in rats. Ataturk University J Vet Sci 13(3):337–346.
Gedikli S, Ozkanlar S, Gur C, Sengul E, Gelen V. Preventive effects of quercetin on liver damages in highfat diet-induced obesity. Journal of Histology & Histopathology. 2017; 4:7
Gedikli S, Şengül E. The Effects Of Quercetin On Cyclophosphamide Induced Hepatotoxicity In The Rats . Dicle Med. J, 2019;46(1), 41-50.
Sengul E, Gelen V, Gedikli S. Cardıoprotectıve actıvıtıes of quercetın and rutın ın sprague dawley rats treated wıth 5-fluorouracıl. Journal of Animal & Plant Sciences . 2021, 31:2 423-431.
Angeloni C, Spencer JP, Leoncini E, Biagi PL, Hrelia S. Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress. Biochimie. 2007 Jan; 89(1):73-82.
Dong Q, Chen L, Lu Q, Sharma S, Li L, Morimoto S, Wang G. Quercetin attenuates doxorubicin cardiotoxicity by modulating Bmi-1 expression. Br J Pharmacol. 2014 Oct; 171 (19): 4440-54
Shanmugarajan TS, Arunsunder M, Somasundaram I, Krishnakumar E, Sivaraman D, Ravichandiran V. Protective effect of Ficus hispida Linn. on cyclophosphamide provoked oxidative myocardial injury in rat model. Int J Pharmacol. 2008; 1: 1–10.
Viswanatha Swamy AH, Patel UM, Koti BC, Gadad PC, Patel NL, Thippeswamy AH. Cardioprotective effect of Saraca indica against cyclophosphamide induced cardiotoxicity in rats: A biochemical, electrocardiographic and histopathological study. Indian J Pharmacol. 2013; 45: 44–8.
Benstoem C, Goetzenich A, Kraemer S. Selenium and its supplementation in cardiovascular disease-what do we know. Nutrients, 2015, 7: 3094-3118.
Alhumaidhaa KA, Salehb DO, Abd El Fattah MA, El-Erakyb WI, Moawada H. Cardiorenal protective effect of taurine against cyclophosphamide-induced toxicity in albino rats. Can J Physiol Pharmacol, 2015, 18: 1-9.
Liu Y, Tan D, Shi L. Blueberry anthocyanins-enriched extracts attenuate cyclophosphamide-induced cardiac injury. PLoS ONE, 2015, 10 (7): IDe0127813.
Matouk AI, Taye A, Heeba GH, El-Moselhy MA. Quercetin augments the protective effect of losartan against chronic doxorubicin cardiotoxicity in rats. Environ Toxicol Pharmacol. 2013, 36(2): 443-50.
Mythili Y, Sudharsan PT, Selvakumar E, Varalakshmi P (2004) Protective effect of dl-lipoic acid on cyclophosphamide induced oxidative cardiac injury. Chem Biol Interact 151:13–19
Gado AM, Adam ANI, Aldahmash BA. Cardiotoxicity induced by cyclophosphamide in rats: protective effect of curcumin. Journal of Research in Environmental Science and Toxicology, 2013, 2(4): 87–95
Shrivastava M, Kar V, Shrivastava S. Cyclophosphamide altered the myocardial marker enzymes: protection provoked by hesperidin in rats. J App Pharm, 2011, 4(3): 407–415.
Kumar S, Dhankhar N, Kar V, Shrivastava M, Shrivastava S. Myocardial injury provoked by cyclophosphamide, protective aspect of hesperidin in rats. IJRPBS, 2011, 2(3): 1288–1295.
Cao G, Sofic E, Prior RL. Antioxidant and prooxidant behavior of flavonoids: structure–activity relationships. Free Radic Biol Med, 1997, 22: 749–760.
Muthukumaran S, Sudheer AR, Menon VP, Nalini N. Protective effect of quercetin on nicotine-induced prooxidant and antioxidant imbalance and DNA damage in Wistar rats. Toxicology, 2008, 243: 207–215.
Haleagrahara N, Radhakrishnan A, Lee N, Kumar P. Flavonoid quercetin protects against swimming stress-induced changes in oxidative biomarkers in the hypothalamus of rats. Eur. J. Pharmacol, 2009, 621: 46–52.
Kupari M, Volin L, Suokas A, et al. Cardiac involvement in bone marrow transplantation: electrocardiographic changes, arrhythmias, heart failure and autopsy findings. Bone Marrow Transplant. 1990, 5: 91-98.
Khodeer DM, Mehanna ET, Abushouk AL, Abdel-Daim MM, Protective effects of evening primrose oil against cyclophosphamide-induced biochemical, histopathological, and genotoxic alterations in mice, Pathogens 9 (2020) 98.
Song Y, Zhang C, Wang C, Zhao L, Wang Z, Dai Z, Lin S, Kang H, Ma X. Ferulic Acid against Cyclophosphamide-Induced Heart Toxicity in Mice by Inhibiting NF-κB Pathway. Evid Based Complement Alternat Med, 2016, 2016:1261270.
Tarek MK, Motawi NAH, Sadik AR. Cytoprotective effects of dl-alpha-lipoic acid or squalene on cyclophosphamide induced oxidative injury: an experimental study on ratmyocardium, testicles and urinary bladder. Food Chem Toxicol, 2010, 48(8–9): 2326–2336
Dhesi S, Chu MP, Blevins G, Paterson I, Larratt L, Oudit GY, Kim DH. Cyclophosphamide-Induced Cardiomyopathy: A Case Report, Review and Recommendations for Management. J Investig Med High Impact Case Rep, 2013, 1; 1 (1): 2324709613480346.
Moirangthem RS, Jitendra SSV, Devi H C, Devi KS, Gunindro N, Devi NM. Effect of Aqueous Extract of Phyllanthus Fraternus Leaf Against Cyclophosphamide Induced Dyslipidemia and Aortitis in Wistar Albino Rats. International Journal of Contemporary Medical Research, 2016, 9: 2703-2706.
Morkin E. Control of cardiac myosin heavy chain gene expression. Microsc Res
Tech. 2000 Sep 15;50(6): 522-31.
Pingitore A, Iervasi G, Barison A, Prontera C, Pratali L, Emdin M, et al. Early activation of an altered thyroid hormone profile in asymptomatic or mildly symptomatic idiopathic left ventricular dysfunction. J Card Fail. 2006; 12: 520–6.
Taneja AK, Gaze D, Coats AJ, Dumitrascu D, Spinarova L, Collinson P, et al. Effects of nebivolol on biomarkers in elderly patients with heart failure. Int J Cardiol. 2014; 175: 253–60.
Alpsoy S, Aktas C, Uygur R, Topcu B, Kanter M, Erboga M, Karakaya O, Gedikbasi
Antioxidant and anti-apoptotic effects of onion (Allium cepa) extract on doxorubicin-induced cardiotoxicity in rats. J Appl Toxicol. 2013 Mar;33(3):202-8.
McCarroll N, Keshava N, Cimino M, Chu M, Dearfield K, Keshava C, Kligerman A, Owen R, Protzel A, Putzrath R, Schoeny R: An evaluation of the mode of action framework for mutagenic carcinogens case study: Cyclophosphamide. Environ Mol Mutagen, 49, 117-131, 2008.
Senthilkumar S, Yogeeta SK, Subashini R, Devaki T: Attenuation of cyclophosphamide induced toxicity by squalene in experimental rats. Chem Biol Interact, 160, 225-260, 2006.
Halliwell B, Gutteridge JM: Lipid peroxidation, oxygen radicals, cell damage, and antioxidant therapy. Lancet, 23, 1396-1397, 1984.
Avci, H., Sekkin, S., BOYACIOĞLU, M., & AKŞİT, H. (2016). Protective and Antigenotoxic Effects of Silymarin and Curcumin in Experimental Cyclophosphamide Intoxication in Rats. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 22(5), 693-701.
Conklin DJ, Haberzettl P, Jagatheesan G, Baba S, Merchant ML, Prough RA, Williams JD, Prabhu SD, Bhatnagar A. Glutathione S-transferase P protects against cyclophosphamide-induced cardiotoxicity in mice. Toxicol Appl Pharmacol. 2015 Jun 1;285(2):136-48.
Dong, Q., Chen, L., Lu, Q., Sharma, S., Li, L., Morimoto, S., & Wang, G. (2014). Quercetin attenuates doxorubicin cardiotoxicity by modulating Bmi‐1 expression. British journal of pharmacology, 171(19), 4440-4454.