Data statement
The data underlying this article cannot be shared due to the privacy of individuals who participated in the study, as stated by the local Ethics Committee (approval no. 2381/2019). Additional aggregated data analyses and the underlying analytic R code are available from the authors upon request.
Author contributions
Andrea De Giglio, MD (Conceptualization; Data curation; Formal Analysis; Investigation; Methodology; Visualization; Writing-original draft; Writing-review and editing), Alessandro Leonetti (Data curation; Formal Analysis; Visualization; Writing-original draft; Writing-review and editing), Francesca Comito, MD (Data curation; Writing-review and editing), Daria Maria Filippini, MD (Data curation; Writing—review and editing), Veronica Mollica, MD (Data Curation; Methodology; Writing—review and editing), Karim Rihawi, MD, (Data Curation; Methodology; Writing-review and editing), Marianna Peroni, MD(Data curation; Writing—review and editing), Giulia Mazzaschi, MD (Data curation; Writing—review and editing),Ilaria Ricciotti, MD (Data curation; writing-review and editing), Francesca Carosi, MD (Data curation; writing-review and editing), Andrea Marchetti, MD (Data curation; writing-review and editing), Matteo Rosellini, MD (Data curation; writing-review and editing), Elisabetta Nobili, MD (Writing-review and editing), Francesco Gelsomino, MD (Writing-review and editing), Barbara Melotti, MD (Writing-review and editing), Paola Valeria Marchese, MD (Writing-review and editing), Francesca Sperandi, MD (Writing-review and editing), Alessandro Di Federico, (Methodology; Writing-review and editing), Sebastiano Buti, MD, (Writing-review and editing), Fabiana Perrone, MD, (Writing-review and editing),Francesco Massari, MD (Writing-review and editing), Maria Abbondanza Pantaleo, MD (Funding, Supervision; Validation; Writing-review and editing),Marcello Tiseo, MD, (Supervision; Validation; Writing-review and editing), Andrea Ardizzoni, MD, (Conceptualization; Project administration; Supervision; Validation; Writing-review and editing).
Funding
The research leading to these results has received funding from the European Union - NextGenerationEU through the Italian Ministry of University and Research under PNRR - M4C2-I1.3 Project PE_00000019 "HEAL ITALIA" to Andrea De Giglio, CUP J33C22002920006. The views and opinions expressed are those of the authors only and do not necessarily reflect those of the European Union or the European Commission. Neither the European Union nor the European Commission can be held responsible for them
Conflicts of interest
ADG, FC, DM, VM, KR, IR,FC, VF, AG, GM, SB, FP, AM,MR,EN,BM,PVM,FS,MAP declare no conflicts of interests.
FG has received personal fees or Advisory roles from Eli-Lilly, Novartis, AstraZeneca, MSD
ADF has received honoraria from Society for Immunotherapy of Cancer and Advisory role from Hansen-Wade.
FM has received research support and/or honoraria from Astellas, BMS, Janssen, Ipsen, MSD and Pfizer outside the submitted work.
AA has received Honoraria for the participation to advisory boards and/or for lectures from BMS, Eli-Lilly, MSD, AZ, Roche, Takeda, Janssen, Sanofi, Novartis, AbbVie, Daiichi
AL has received speakers’ fee for Astra-Zeneca, MSD, Takeda and Sanofi. AL has been on advisory board for BeiGene, Sanofi, Novartis, Astra-Zeneca. AL has attended editorial activities sponsored by Roche and Eli Lilly. AL has received travel support from MSD and Novartis.
MT received speakers’ and consultants’ fee from Astra-Zeneca, Pfizer, Eli-Lilly, BMS, Novartis, Roche, MSD, Boehringer Ingelheim, Otsuka, Takeda, Pierre Fabre, Amgen, Merck, Sanofi. MT received institutional research grants from Astra-Zeneca, Boehringer Ingelheim.
Acknowledgements
No acknowledgements