To favour farmers and adjusting their farming practices, long term weather analyses is essential to determine future directions and making adjustments required to existing systems. The main purpose of this study was thus to analyze the variability and trends of climatic variables (temperature and rainfall) and characteristics of crop growth season in Eastern zone of Tigray region for the period of 1980–2009. Detail investigations were carried out using parametric (Linear regression) and non-parametric tests (Mankendall and Sen’s slope estimator). Moreover, homogeneity test was applied using a method developed by Van Belle and Hughes for the general trend analysis. Furthermore, the trend of rainfall end to characterize crop growth season using R-Instat and XLSTAT software. It was found that the general trend of monthly rainfall experienced an overall significant increasing trend. The seasonal rainfall experienced significantly increasing trend during the summer rainy season (June–September) whilst a significant decreasing trend occurred in the short rainy season (February–May). Likewise, the seasonal maximum temperature trends exhibited a significant increasing trend in all seasons whereas the minimum temperature showed inhomogeneous trend across seasons as well as stations. Despite significant increase of rainfall in summer season, the trend of growing season characteristics (onset, cessation, length of growing period and dry spell length) did not change significantly over the study period. However, the variability of rainfall and dry spell length was found to be very large. Hence, crop production in the study area demands appropriate adaptation strategies that considers the erratic nature of the rainfall, the long dry spell length in the season and increasing trends of temperature.