Moayeddi et al, 2015 | Total Mayo score < 3 AND Endoscopic Mayo score = 0 | Mayo score reduction ≥ 3 Not reported | Not reported Endoscopic Mayo subscore = 0 |
Rossen et al, 2015 | SCCAI ≤ 2 AND Mayo endoscopic score reduction ≥ 1 | SCCAI reduction ≥ 1.5 SCCAI ≤ 2 | Endoscopic Mayo score reduction by ≥ 1 Mayo endoscopic score = 0 |
Paramsothy et al, 2017 | Total Mayo score ≤ 2 AND Endoscopic subscore reduction ≥ 1 | Mayo score reduction by ≥ 3 Mayo subscores ≤ 1 | Endoscopic Mayo subscore ≤ 1 Endoscopic Mayo score = 0 |
Costello et al, 2019 | Total Mayo score ≤ 2 AND Endoscopic Mayo subscore ≤ 1 | Mayo score reduction by ≥ 3 SCCAI ≤ 2 | Not reported Endoscopic Mayo subscore = 0 |
Crothers et al, 2021 | Modified Mayo Score ≤ 2 AND Endoscopic Mayo sub-score ≤ 1 | Mayo score reduction by ≥ 3 Not reported | Not reported Not reported |
Haifer et al, 2021 | Total Mayo score ≤ 2 AND Endoscopic Mayo subscores ≤ 1 AND Endoscopic Mayo subscore reduction by ≥ 1 | Mayo score reduction by ≥ 3 Mayo subscores ≤ 1 | UCEIS reduction by ≥ 3 UCEIS ≤ 1 |
Sood et al, 2019 | Not reported | Not reported Mayo score ≤ 2 AND all subscores ≤ 1 | Not reported Endoscopic Mayo score = 0 |
Yang et al, 2019 | CDAI < 150 OR a decrease in SES-CD to 0–2. | CDAI decrease > 100 CDAI < 150 | SES-CD decrease > 50% Decrease in SES-CD to 0–2 |
Crothers et al, 2018 | Total Mayo score < 3 with decrease in Mayo endoscopic subscore ≥ 1 | Mayo score reduction by ≥ 3 Mayo score < 3 | Decrease in Mayo subscore > 1 or UCEIS > 2 Not reported |
Herfath et al, 2019 | Not reported | Decrease of mPDAI clinical subscore > 2 points AND no need for antibiotic therapy Clinical mPDAI score ≤ 4 points AND decrease of mPDAI > 2 points AND no need for antibiotic therapy. | Decrease from baseline in mPDAI endoscopic subscore > 2 points. Not reported |
Single Blind Randomized Controlled trials |
Wei et al, 2016 | Not reported | Reduction of > 30% in total Mayo score from baseline, a 1-point improvement in tarry stools or IBDQ increase by > 16 points Total Mayo score ≤ 2 | Not reported Not reported |
Sokol et al, 2020 | Not reported | Not reported CDAI < 150 | Not reported SES-CD ≤ 2 |
Open label Randomized Controlled trials |
Fuentes et al, 2017 | Not reported | Not reported SCCAI ≤ 2 AND Mayo Endoscopic Score reduction ≥ 1 | Not reported Not reported |
Scheirova et al, 2020 | Endoscopic remission defined as an endoscopic Mayo score of 0. | Mayo score reduction by ≥ 2 Mayo score ≤ 2, with no subscore > 1 | Not reported Endoscopic Mayo score = 0 |
Fang et al, 2021 | Total Mayo score of 2 and Endoscopic Mayo score = 1 | Decrease in Mayo score of ≥ 30% and ≥ 3 points Mayo score ≤ 2 with each subscore ≤ 1 | Not reported Endoscopic Mayo subscore ≤ 1 |
Non randomized trials |
Ishikawa et al, 2017 NRT | Not reported | CAI < 10 points and a decrease of ≥ 3 points CAI ≤ 3 | Not reported Not reported |
Scaldaferri et al, 2015 | Not reported | Mayo score reduction ≥ 2 Mayo score ≤ 2 with no subscore ≥ 1 | Not reported Endoscopic Mayo subscore = 0 |
Observational Studies |
Angelberger et al, 2013 OS | Not reported | Mayo score reduction ≥ 3 AND ≥ 30% along with drop in bleeding subscore ≥ 1 or bleeding subscore ≤ 1 Total Mayo score ≤ 2 AND no subscore > 1 | Not reported NR |
Kunde et al, 2013 | Not reported | PUCAI drop > 15 PUCAI < 10 | Not reported Not reported |
Kump et al, 2013 | Not reported | Mayo score reduction ≥ 3 Total Mayo score ≤ 2 | Not reported Not reported |
Cui et al, 2015 (CD) | Not reported | HBI score reduction >3 HBI score ≤ 4. | Not reported Not reported |
Cui et al, 2015 (UC) | Not reported | Montreal improvement ≥ 1 Montreal class 0 | Not reported Not reported |
Ren et al, 2015 | Not reported | Mayo score reduction ≥ 3 AND ≥ 30% Mayo score ≤ 2 AND all subscores ≤ 1 | Not reported Not reported |
Damman et al, 2015 | Not reported | UCDAI drop ≥ 3 UCDAI ≤ 2 AND no subscore > 1 | Not reported Not reported |
Suskind et al (UC), 2015 | Not reported | PUCAI drop > 15 PUCAI < 10 | Not reported Not reported |
Suskind et al (CD), 2015 | Not reported | Not reported PCDAI < 10 | Not reported Not reported |
Wei et al, 2015 | Not reported | IBDQ score increase of > 16 OR CDAI score by > 70 OR Mayo score > 1 IBDQ score > 170 OR CDAI score < 150 OR Mayo score < 2 in UC. | Not reported Not reported |
Kump et al, 2015 | Not reported | Mayo score reduction ≥ 3 Total Mayo score ≤ 2 | Not reported Not reported |
Kellermayer et al, 2016 | Not reported | Not reported PUCAI < 10 | Not reported Not reported |
Lazlo et al, 2016 | Not reported | Not reported Not reported | Not reported Mayo score reduction ≥ 3 |
Zhang et al, 2016 | Not reported | Mayo score reduction ≥ 3 AND ≥ 30% along with drop in bleeding subscore ≥ 1 or bleeding subscore ≤ 1 Total Mayo score ≤ 2 and no subscore > 1 | Not reported Not reported |
Vermeire et al, 2016 | Not reported | Not reported Not reported | Not reported Mayo endoscopic subscore ≤ 1 for UC and SES-CD < 3 for CD. |
Vaughn et al, 2016 | Not reported | HBI decrease ≥ 3 HBI < 5 | Not reported Not reported |
Karakan et al, 2016 | Not reported | Mayo score reduction ≥ 3 AND ≥ 30% Mayo score ≤ 2 | Not reported Not reported |
Jacob et al, 2016 | Not reported | Mayo score reduction ≥ 3 AND bleeding subscore ≤ 1 Total Mayo score ≤ 2 and no subscore > 1 | Not reported Endoscopic Mayo subscore = 0 |
Grewal et al, 2016 | Not reported | Mayo score reduction ≥ 2 Mayo score ≤ 2 with no subscore ≥ 1 | Not reported Endoscopic Mayo subscore = 0 |
Mizuno et al, 2017 | Not reported | Mayo scores ≤ 2 Not reported | Not reported Not reported |
Uygun et al, 2017 | Mayo score ≤ 2 points and complete mucosal healing (Mayo endoscopic subscore ≤ 1). | Mayo score reduction ≥ 3 AND ≥ 30% Mayo score ≤ 2 with no subscore ≥ 1 | Endoscopic Mayo subscore ≤ 1 Endoscopic Mayo score = 0 |
Nishida et al, 2017 | Not reported | Mayo score reduction ≥ 3 AND ≥ 30% along with drop in bleeding subscore ≥ 1 or bleeding subscore ≤ 1 Total Mayo score ≤ 2 and no subscore > 1 | Mayo endoscopy subscore of 1 or less. Not reported |
Karolewska-Bochenek et al, 2017 | Not reported | PUCAI or PCDAI decrease ≥ 15 PCDAI score ≤ 10 for CD and a PUCAI score < 10 for UC | Not reported Not reported |
Kump et al, 2018 | Not reported | Mayo score reduction ≥ 3 Total Mayo score ≤ 2 | Not reported Endoscopic Mayo subscore < 1 |
Goyal et al, 2018 | Not reported | PUCAI reduction > 15 PUCAI = 0 points | Not reported Not reported |
Wang et al, 2018 | Not reported | HBI decrease >3 HBI ≤4 | Not reported Not reported |
Xiang et al, 2019 | Not reported | HBI decrease >3 HBI ≤4 | Not reported Not reported |
Gutin et al, 2019 | Not reported | HBI decrease ≥3 HBI < 3 | Improvement in SES-CD score Not reported |
Zou et al, 2019 | Not reported | HBI decrease > 3 for CD and Mayo score decrease > 3 for UC Not reported | Not reported Not reported |
Cold et al, 2019 | Not reported | SCCAI reduction ≥ 1.5 SCCAI ≤ 2 | Not reported Not reported |
Sood et al, 2019 | Not reported | Mayo score reduction ≥ 3 AND ≥ 30% Total Mayo score ≤ 2 with subscore ≤ 1 | Not reported Mayo score 0 or 1 |