Diseases like Clostridioides difficile infections are intimately connected with imbalances in the microbial community in our gut. Rebalancing the gut microbiota with fecal transplants can help treat these diseases, but the current donor screening process is costly and complex. C. diff infections have previously successfully been treated with transplantation of healthy fecal microbiotas or fecal ‘viromes’. The viral community, or virome, in the gut contains viruses that specifically infect bacteria, called ‘phages’, that can reshape the bacterial community. However, concerns about human viral pathogens within the virome limit the use of this technique, especially if the illness is not severe. But a recent study tested several processing methods that reduce the virome to mainly phages. In C. difficile-infected mice, the processed viromes broadly reduced disease severity and progression more than whole microbiota transplantation and saline. Further, one of the processing methods appeared to eliminate C. difficile despite all other methods only reducing the pathogen’s numbers. While more research is needed, this study suggests that modified virome transplantation could be safe and consistent, and opens the way to treatments for many gut-related diseases.