The effects of inter-particle spacing and radius of molybdenum disulfide nanoparticle on nanofluid flow have significant applications in various fields. In biomedical engineering, optimizing these parameters enhance drug delivery systems, enabling more efficient targeting and controlled release of therapeutics. For such important applications, this work investigates nanofluid flow on a bi-directional elongating surface with effects of inclined magnetic field. The surface of sheet is characterized with variable porous features. This work specifically examines how the radii of nanoparticles and the spaces between them influence the overall dynamics of flow system. The Cattaneo-Christov heat and mass flux model is also taken into consideration to investigate the heat and mass flow. The impacts of chemical reaction and activation energy have used in this work with, Brownian motion and thermophoresis impacts. Main equations have converted to dimensionless form and then solved by implementing bvp4c approach. It has revealed in this work that with upsurge in magnetic factor, angle of inclination of magnetic field and variable porous factor there is reduction in primary and secondary velocities both for inter-particles spaces (say\(h=1/2\,\,\& \,\,10\)) and radius of nanoparticles (say\(Rp=3/2\,\,\& \,\,5/2\)). This reduction is more significant in case of large inter-particles spaces (say\(h=\,\,10\)) and large radius of nanoparticles (say\(Rp=\,5/2\)). With growth in radiation factor, thermal Biot number, and Brownian motion factor there is escalation in thermal distribution. The findings from this study can be utilized in designing drug carriers with controllable porous structures, allowing for the regulation of drug movement and release rates within the body. For example, carriers with larger inter-particle spaces can be engineered to provide a slower, more controlled drug release. This approach ensures sustained delivery to target sites, thereby enhancing therapeutic efficacy.