Efficacy and safety of trastuzumab deruxtecan in HER2-positive breast cancer patients with brain metastases after failure of pyrotinib-based therapy

doi:10.21203/rs.3.rs-5022718/v1

Download PDF

Research Article

Efficacy and safety of trastuzumab deruxtecan in HER2-positive breast cancer patients with brain metastases after failure of pyrotinib-based therapy

https://doi.org/10.21203/rs.3.rs-5022718/v1

This work is licensed under a CC BY 4.0 License

You are reading this latest preprint version

Purpose:

Tyrosine kinase inhibitors (TKIs) and trastuzumab deruxtecan (T-DXd) have shown efficacy in HER2-positive patients with brain metastasis (BMs). This paper analyzed the efficacy and safety of T-DXd in HER2-positive breast cancer patients with BMs who progressed after pyrotinib treatment.

Methods:

We conducted a single-center, retrospective cohort study. HER2-positive patients with BMs received T-DXd treatment that previously received pyrotinib therapy and progressed were identified from electronic medical records. The primary endpoint of this study was central nervous system progression-free survival (CNS-PFS).

Results:

From April 2021 to July 2023, 15 patients were included in the study. The median CNS-PFS was 7.4 months [95% confidence interval (CI), 6.1–8.8 months], the median PFS for patients with extracranial/total lesions was 6.4 months (95% CI, 4.4–8.3 months), and the median OS was 9.8 months (95% CI, 5.9–13.8 months). The ORR rates for intracranial, extracranial, and overall lesions were 33.3%, 71.4%, and 73.3%, respectively. Adverse events of grade 3 or higher with an incidence rate ≥ 5% included leukopenia (20.0%), neutropenia (13.3%), thrombocytopenia (6.7%), and nausea (6.7%). Adverse events of specific interest, interstitial lung disease or pneumonitis, occurred in 2 patents (13.3%), and both were grade 1.

Conclusions:

The preliminary data in this study suggest that in clinical practice in China, T-DXd is an optional treatment for patients with active/stable BMs who have progressed on pyrotinib. However, further studies are needed to determine its efficacy and the best treatment sequence for these patients.

Breast cancer

HER2-positive

brain metastases

trastuzumab deruxtecan

Human epidermal growth factor receptor 2 (HER2) is overexpressed in approximately 20–30% of breast cancers, and its increased expression indicates aggressive tumor biology and poor prognosis. The development of anti-HER2 targeted drugs has significantly improved the prognosis of HER2-positive breast cancer patients. Up to 50% of patients with advanced HER2-positive breast cancer develop brain metastases (BMs), which significantly shorten the survival time.^{[1, 2]} Local therapy, such as surgery and radiotherapy, is an important strategy for patients with BMs, but systemic anti-HER2 regimens also show promising therapeutic potential.^[3]

Anti-HER2 drugs are divided into three categories: monoclonal antibodies, tyrosine kinase inhibitors (TKIs), and antibody‒drug conjugates (ADCs). TKIs have the advantages of a small molecular size and a strong ability to penetrate the blood‒brain barrier. To date, more evidence of the effectiveness of TKIs in the treatment of BMs has been reported. Phase 2 LANDSCAPE and TBCRC-022 demonstrated the efficacy of lapatinib and neratinib combined with capecitabine, respectively, in treating patients with BMs.^[4][5] The first phase 3 randomized clinical trial, HER2CLIMB, confirmed the efficacy of tucatinib in treating active/stable BMs. Therefore, tucatinib combined with trastuzumab and capecitabine has become the preferred treatment for HER2-positive breast cancer patients with active BMs.^{[6, 7]} Tucatinib has not yet been approved for use in China. Pyrotinib, which was independently developed in China, has shown clinical effectiveness in treating active/stable BMs and is widely used in clinical practice in China.^[8]

Trastuzumab deruxtecan (T-DXd), a new-generation anti-HER2 ADC drug, has shown promising anticancer efficacy^[9–11] and has been approved for patients with unresectable or metastatic HER2-positive breast cancer who have received one or more prior anti-HER2-based regimens. The DESTINY-Breast01-03 clinical studies included a small number of patients with stable BMs and showed a good objective response rate and duration of response.^[10–13] Currently, retrospective studies and small-scale clinical studies are exploring the efficacy of T-DXd in HER2-positive patients with active BMs.^[14][15] Five HER2-positive patients with BMs treated with T-DXd after tucatinib progression showed satisfactory therapeutic effects.^[16] In Chinese clinical practice, the efficacy and safety of T-DXd in patients with BMs after failure of pyrotinib-based treatment are unknown. This paper analyzed the efficacy and safety of T-DXd in HER2-positive breast cancer patients with BMs who progressed after pyrotinib-based treatment.

This was a single-center, retrospective cohort study. Metastatic breast cancer (MBC) patients who received T-DXd treatment were identified from electronic medical records. All patients were then screened for eligibility based on the following criteria: (1) age ≥ 18 years; (2) pathologically diagnosed with HER2-positive breast cancer, defined as positive by immunohistochemistry (IHC) staining (+++) or fluorescence in situ hybridization (FISH) positivity; (3) radiologically confirmed BMs; (4) progression of BMs during prior pyrotinib-based therapy, defined as the development of new BMs during pyrotinib-based therapy or progression of preexisting BMs; (5) performance-status score on the Eastern Cooperative Oncology Group (ECOG) scale ≤ 3; (6) at least one efficacy assessment after T-DXd treatment; (7) adequate bone marrow and organ function; and (8) complete medical records. The study protocol was approved by the Ethics Committee of the Fifth Medical Center of Chinese People's Liberation Army General Hospital, and all patients provided written informed consent.

Study treatment

Patients received T-DXd at the recommended dose of 5.4 mg/kg by intravenous infusion every 21 days. Dose reduction, interruption, delay, or treatment discontinuation were considered in the case of adverse reactions. The adverse events were promptly managed according to the guidelines. Treatment lasted until disease progression or unacceptable toxicity occurred or for any other reason.

Outcomes

The primary endpoint of this study was central nervous system progression-free survival (CNS-PFS), which indicates the time interval from treatment to disease progression in intracranial lesions or to death from any cause. The secondary endpoints included the objective response rate (ORR) for intracranial, extracranial and overall lesions; the clinical benefit rate (CBR) for intracranial, extracranial and overall lesions; overall survival (OS); and safety. The ORR is defined as the percentage of patients who achieve the best overall response (CR) rate and the percentage of patients who achieve a partial response (PR) rate based on investigator assessment. The CBR is defined as the sum of the CR rate, PR rate, and stable disease (SD) rate for more than 6 months. OS was defined as the time interval from treatment to death from any cause. Tumor imaging assessment was performed every two cycles or when disease progression was suspected clinically based on symptoms and signs until disease progression or death. Efficacy in intracranial lesions was evaluated based on the Response Assessment in Neuro-Oncology-Brain Metastases (RANO-BM) criteria, while that of extracranial/overall lesions was based on the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. Safety assessments included vital sign and clinical laboratory evaluations, and adverse events were evaluated according to the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. When interstitial lung disease or pneumonia was suspected, early diagnosis was made through high-resolution CT, laboratory tests, and consultation with a respiratory specialist. In moderate to severe cases, T-DXd was discontinued, and steroids were administered.

Statistical analysis

Statistical analysis was performed using SPSS 26.0 software. Qualitative data were presented as sample rates or frequencies, and intergroup differences were compared by using chi-square or Fisher's exact tests. Kaplan‒Meier (K‒M) curves were used to analyze and calculate PFS and OS, and log-rank tests were used for comparison.

Patient characteristics

From April 2021 to July 2023, 48 patients with metastatic cancer were selected for treatment with T-DXd. Among them, 20 patients had BMs, and 15 patients previously received pyrotinib therapy and experienced disease progression (Fig. 1). The median age of the patients was 51 years (32–66), and 5 patients were positive for hormone receptors. A total of 14 patients had extracranial metastases and intracranial metastases. The median number of metastatic sites was 5 (1–6). The median number of therapy lines for T-DXd was 7 (3–12). All patients in the study previously received trastuzumab and pyrotinib, 13 patients (86.7%) previously received pertuzumab therapy, and 9 patients (60%) previously received T-DM1. After being diagnosed with BMs, 13 patients (86.7%) received trastuzumab plus pertuzumab, 8 patients (53.3%) received pyrotinib, and 5 patients (33.3%) received T-DM1. The median number of anti-HER2 therapy lines before T-DXd was 2 (0–5) after the diagnosis of BMs. Seven patients (46.7%) previously received whole-brain radiotherapy ± stereotactic radiotherapy, 6 patients (40.0%) received stereotactic radiotherapy ± surgery, and 2 did not receive local therapy for BMs. The median time between the initiation of T-DXd treatment and the last local therapy for BMs was 8.1 months (1.1–36.8 months). Nine patients (60.0%) had active BMs (new BMs or progressive BMs), 6 patients (40.0%) had stable BMs (received prior local treatment and remained stable), and 10 (66.7%) of the patients had multiple BMs. Six patients (40.0%) experienced symptoms such as dizziness, headache, nausea, or others related to BMs (Table 1).

Table 1

Patient demographics (n = 15)
Characteristic	No. (%)
Age (years)
Median (range)	51 (32–66)
ECOG performance status
0	2 (13.3%)
1	8 (53.3%)
2	3 (20.0%)
3	2 (13.3%)
Hormone receptor status
ER/PR positive	5 (33.3%)
ER and PR negative	10 (66.7%)
HER2 status
IHC 3+	14 (93.3%)
IHC 2+/ISH+	1 (6.7%)
Extracranial metastases	14 (93.3%)
Target lesion
Intracranial	9 (60.0%)
Extracranial	14 (93.3%)
Intracranial and extracranial	15 (100%)
Number of metastasis sites
1	1 (6.7%)
2	0 (0.0%)
≥3	14 (93.3%)
Metastasis sites
Bone	11 (73.3%)
Visceral	14 (93.3%)
Liver	9 (60.0%)
Lung	10 (66.7%)
Brain	15 (100%)
Brain metastases status
Active	9 (60.0%)
Stable	6 (40.0%)
Time from breast cancer diagnosis to brain metastases (months)
Median (range)	41.0 (4.6–88.9)
Time from metastases breast cancer diagnosis to brain metastases (months)
Median (range)	19.2 (0-69.6)
Symptoms of brain metastases
Yes	6 (40.0%)
No	9 (60.0%)
Prior local therapy for brain metastases
Surgery	2 (13.3%)
Whole-brain radiation therapy	7 (46.7%)
Stereotactic radiotherapy	8 (53.3%)
Time from last local brain treatment to enrollment (months)
Median (range)	8.1 (1.1–36.8)
Previous anti-HER2 therapy
Trastuzumab	15 (100%)
Pertuzumab	13 (86.7%)
T-DM1	9 (60.0%)
Pyrotinib	15 (100%)
Anti-HER2 therapy after brain metastases
Trastuzumab	13 (86.7%)
Pertuzumab	11 (73.3%)
T-DM1	5 (33.3%)
Pyrotinib	8 (53.3%)
Number of prior lines of anti-HER2 therapy for MBC
Median (range)	5(2–9)
2	2 (13.3%)
≥3	13 (86.7%)
Number of prior lines of chemotherapy for MBC
Median (range)	5 (2–11)
2	2 (13.3%)
≥3	13 (86.7%)
Number of treatment lines from the time of brain metastases diagnosis to enrollment
Median (range)	2 (0–5)
0	1 (6.7%)
1	3 (20.0%)
≥ 2	11 (73.3%)
Line of T-DXd treatment
Median (range)	7 (3–12)
3	1 (6.7%)
≥4	14 (93.3%)
ECOG, Eastern Cooperative Oncology Group; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2; IHC, immunohistochemistry; ISH, in situ hybridization; T-DXd, trastuzumab deruxtecan; MBC, metastatic breast cancer

Efficacy

As of September 2023, the median follow-up time was 8.6 months (2.1–23.3 months). Five patients continued T-DXd treatment, 10 patients discontinued treatment due to disease progression, 6 of whom experienced simultaneous intracranial and extracranial progression, and 4 of whom experienced only extracranial progression. Eight patients (57.1%) died due to progression of breast cancer. The median CNS-PFS was 7.4 months [95% confidence interval (CI), 6.1–8.8 months] (Fig. 2A), the median PFS for patients with extracranial/total lesions was 6.4 months (95% CI, 4.4–8.3 months) (Fig. 2B), and the median OS was 9.8 months (95% CI, 5.9–13.8 months) (Fig. 2C).

Of the 15 patients included in the study, 9 had evaluable intracranial lesions, and 14 had evaluable extracranial lesions. The ORR rates for intracranial, extracranial, and overall lesions were 33.3%, 71.4%, and 73.3%, respectively, while the CBR rates for intracranial, extracranial, and overall lesions were 53.3%, 66.7%, and 73.3%, respectively. The median time to response was 1.5 months for intracranial lesions, 1.4 months for extracranial lesions, and 1.6 months for overall lesions, while the median duration of response was 4.9 months for intracranial lesions, 5.7 months for extracranial lesions, and 6.0 months for overall lesions (Fig. 3).

Nine patients had active BMs, of whom 8 had target lesions in the brain, and 7 progressed after previous local treatment. Three patients achieved PR in their intracranial lesions, all of whom had progressed after previous local BM treatment (Fig. 4). Six patients presented with symptoms related to BMs, such as dizziness and nausea, 4 of whom experienced symptom alleviation after T-DXd treatment. Six patients had stable BMs, of whom 1 had a target lesion in the brain and none presented with symptoms related to BMs. The intracranial ORR, CBR, CNS-PFS, and OS in patients with active BMs were 33.3%, 44.4%, 7.4 months, and 8.3 months, respectively, while those in patients with stable BMs were 0%, 71.4%, 7.0 months, and 20.3 months, respectively (Fig. 5).

Safety

Treatment-emergent adverse events in 5% or more of the patients are shown in Table 2, most of which were grade 1/2 and thus controllable. Adverse events of grade 3 or higher with an incidence rate ≥ 5% included leukopenia (20.0%), neutropenia (13.3%), thrombocytopenia (6.7%), and nausea (6.7%). Adverse events of specific interest, interstitial lung disease or pneumonitis, occurred in 2 patents (13.3%), and both were grade 1. Two patients had a dose reduction of T-DXd due to nausea and vomiting of Grade 2.

Table 2

Treatment-emergent adverse events in 5% or more of the patients (n = 15)
Event, No. (%)	Any grade	Grade ≥ 3
Anemia	10 (66.7%)	0 (0.0%)
Leukocytopenia	6 (40.0%)	3 (20.0%)
Neutropenia	6 (40.0%)	2 (13.3%)
Thrombocytopenia	3 (20.0%)	1 (6.7%)
Lymphocyte count decreased	9 (60.0%)	1 (6.7%)
Hypokalemia	4 (26.7%)	0 (0.0%)
Elevated AST	7 (46.7%)	0 (0.0%)
Elevated ALT	3 (20.0%)	0 (0.0%)
Elevated bilirubin	3 (20.0%)	0 (0.0%)
Nausea	14 (93.3%)	1 (6.7%)
Vomiting	7 (46.7%)	0 (0.0%)
Diarrhea	1 (6.7%)	0 (0.0%)
Constipation	3 (20.0%)	0 (0.0%)
Stomatitis	2 (13.3%)	0 (0.0%)
Fatigue	13 (86.7%)	0 (0.0%)
Palpitation	1 (6.7%)	0 (0.0%)
Headache	2 (13.3%)	0 (0.0%)
Xerophthalmia	2 (13.3%)	0 (0.0%)
Rash	1 (6.7%)	0 (0.0%)
ILD/pneumonitis	2 (13.3%)	0 (0.0%)
Decreased ejection fraction	0 (0.0%)	0 (0.0%)
Prolonged QT interval	0 (0.0%)	0 (0.0%)
AST, aspartate transaminase; ALT, alanine aminotransferase; ILD, interstitial lung disease

In recent years, the incidence of BMs has increased due to prolonged survival caused by novel systemic therapy regimens and improvements in screening and diagnosis for asymptomatic BMs. Patients with BMs usually have a poor prognosis and a poor quality of life, which is a significant challenge in clinical practice. In addition to local therapy for BMs, systemic anti-HER2 treatment also benefits patients with HER2-positive breast cancer. International guidelines recommend that tucatinib plus trastuzumab and capecitabine be the preferred therapy for patients with active BMs, while patients with stable BMs should receive T-DXd first.^[17] Tucatinib is not yet approved for use in China, and T-DXd is not listed on the national reimbursement drug list, thus limiting its availability. The PERMEATE study showed that pyrotinib combined with capecitabine had an ORR of 74.6% and 42.1% for untreated patients and previously locally treated patients with active BMs, respectively. The PFS times were 11.3 and 5.6 months, respectively. Hence, pyrotinib is widely used in clinical practice in China.^[8] This study is the first to analyze the efficacy and safety of T-DXd in HER2-positive breast cancer BM patients who were previously treated with pyrotinib and who progressed. T-DXd showed good intracranial and extracranial antitumor activity as well as manageable adverse reactions.

In this study, six patients with stable BMs after failure of prior pyrotinib-based therapy were treated with T-DXd. The extracranial ORR was 100%, the CBR was 100%, the median PFS was 7.0 months, and the median OS was 20.3 months. One patient's intracranial lesions were assessable, with a response of SD; the intracranial CBR was 66.7%, and the median CNS-PFS was 7.0 months. The efficacy was inferior to the data reported in the DESTINY-Breast01-03 studies, possibly because the patients enrolled in this study had a greater tumor burden and greater refractoriness. All patients had visceral metastases and failed prior anti-HER2 therapies, including trastuzumab, T-DM1, and pyrotinib, with a median treatment line ≥ 6. In the DESTINY-Breast01-03 studies, the proportion of patients previously treated with TKIs was only 11.5%.^{[10, 12, 13, 18]} Retrospective analysis of data from the KAMILA study showed that PFS and OS were 5.5 and 18.9 months, respectively, and the intracranial CBR was 42.9% in patients with stable BMS treated with T-DM1 with fewer prior treatment lines, visceral metastases, and lapatinib treatment than that of this study.^[19] This suggested that T-DXd could be used as a treatment regimen for patients with stable BMs after failure of pyrotinib-based therapy.

Active BMs, especially in patients who have failed after previous local treatment, have always been a clinical challenge. This study demonstrated the efficacy of T-DXd in 9 patients with active BMs after failure of pyrotinib-based therapy. The extracranial ORR was 44.4%, the median PFS was 6.4 months, the median OS was 8.3 months, 8 patients with measurable intracranial lesions were evaluated, the intracranial ORR was 33.3%, the CBR was 44.4%, the median intracranial PFS was 7.4 months, and 4 of the 6 patients with baseline BM symptoms experienced symptom relief after T-DXd treatment. The efficacy of T-DXd in this study was inferior to that reported in studies by TUXEDO and DEBBRAH, possibly due to the greater tumor burden and refractoriness of the patients enrolled in this study, limited palliative care after T-DXd progression, and previous pyrotinib-based failure.^[14],[15] The median time from the last local brain treatment to enrollment in this study was 8.1 months, which was significantly shorter than the 13 months reported in TUXEDO, suggesting that the patients in this study had faster disease progression and greater malignancy. Isabelle Desmoulins reported that 5 patients with active BMs who received T-DXd after progression of tucatinib had an intracranial ORR of 100%. The possible reason for the different results observed in this study is that pyrotinib and tucatinib have different mechanisms of action. Pyrotinib is an irreversible inhibitor of HER1, HER2, and HER4, while tucatinib is a highly selective inhibitor of HER2.^[16]

The adverse reaction profile of T-DXd patients was consistent with that in previous reports, and the incidence of grade 3 or higher neutropenia was similar to that in previous reports. The use of prophylactic triple antiemetics resulted in no grade 3 nausea/vomiting, and the incidence of ILD/pneumonia was relatively low, with no grade 2–5 events.

This study has several limitations. This was a retrospective and single-center study. T-DXd was only approved in China in 2023 and has not yet been included in the national reimbursement list, thus limiting its availability. As a result, the sample size was relatively small, patient selection bias and significant differences in patients’ prior treatments existed, and the follow-up time was short. However, this study provides the first data on the efficacy and safety of T-DXd in the treatment of patients with active/stable BMs who have progressed on pyrotinib, providing an idea, for urgent challenges facing clinical practice.

Ethics approval and consent to participate:

This single-center, retrospective cohort study has been approved by the Ethics Committee of the Fifth Medical Center of Chinese People's Liberation Army General Hospital (approval number: 2021-6-11). All patients provided written informed consent.

Data sharing statement:

The datasets used and/or analyzed in the current study are available from the corresponding author upon reasonable request.

Competing interests:

The authors have declared no competing interests.

Funding:

None.

Author’s contributions:

Conception/design: Zefei Jiang, Tao Wang. Provision of study material or patients: Jinmei Zhou, Jinyi Xiao, Xuexue Wu, Xiaobo Wang, Li Bian, Shaohua Zhang. Data analysis and interpretation: Jinmei Zhou, Jinyi Xiao, and Tao Wang. Manuscript writing: Jinmei Zhou, Jinyi Xiao, and Xuexue Wu. Final approval of manuscript: all authors.

Acknowledgments

None.

Choong GM, Cullen GD, O'Sullivan CC. Evolving standards of care and new challenges in the management of HER2-positive breast cancer. CA Cancer J Clin. 2020. 70(5): 355-374.
Müller V, Bartsch R, Lin NU, Montemurro F, Pegram MD, Tolaney SM. Epidemiology, clinical outcomes, and unmet needs of patients with human epidermal growth factor receptor 2-positive breast cancer and brain metastases: A systematic literature review. Cancer Treat Rev. 2023. 115: 102527.
Gennari A, André F, Barrios CH, et al. ESMO Clinical Practice Guideline for the diagnosis, staging and treatment of patients with metastatic breast cancer. Ann Oncol. 2021. 32(12): 1475-1495.
Bachelot T, Romieu G, Campone M, et al. Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (LANDSCAPE): a single-group phase 2 study. Lancet Oncol. 2013. 14(1): 64-71.
Freedman RA, Gelman RS, Anders CK, et al. TBCRC 022: A Phase II Trial of Neratinib and Capecitabine for Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases. J Clin Oncol. 2019. 37(13): 1081-1089.
Lin NU, Borges V, Anders C, et al. Intracranial Efficacy and Survival With Tucatinib Plus Trastuzumab and Capecitabine for Previously Treated HER2-Positive Breast Cancer With Brain Metastases in the HER2CLIMB Trial. J Clin Oncol. 2020. 38(23): 2610-2619.
Lin NU, Murthy RK, Abramson V, et al. Tucatinib vs Placebo, Both in Combination With Trastuzumab and Capecitabine, for Previously Treated ERBB2 (HER2)-Positive Metastatic Breast Cancer in Patients With Brain Metastases: Updated Exploratory Analysis of the HER2CLIMB Randomized Clinical Trial. JAMA Oncol. 2023. 9(2): 197-205.
Yan M, Ouyang Q, Sun T, et al. Pyrotinib plus capecitabine for patients with human epidermal growth factor receptor 2-positive breast cancer and brain metastases (PERMEATE): a multicentre, single-arm, two-cohort, phase 2 trial. Lancet Oncol. 2022. 23(3): 353-361.
Modi S, Saura C, Yamashita T, et al. Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer. N Engl J Med. 2020. 382(7): 610-621.
André F, Hee Park Y, Kim SB, et al. Trastuzumab deruxtecan versus treatment of physician's choice in patients with HER2-positive metastatic breast cancer (DESTINY-Breast02): a randomised, open-label, multicentre, phase 3 trial. Lancet. 2023. 401(10390): 1773-1785.
Hurvitz SA, Hegg R, Chung WP, et al. Trastuzumab deruxtecan versus trastuzumab emtansine in patients with HER2-positive metastatic breast cancer: updated results from DESTINY-Breast03, a randomised, open-label, phase 3 trial. Lancet. 2023. 401(10371): 105-117.
Jerusalem G, Park YH, Yamashita T, et al. Trastuzumab Deruxtecan in HER2-Positive Metastatic Breast Cancer Patients with Brain Metastases: A DESTINY-Breast01 Subgroup Analysis. Cancer Discov. 2022. 12(12): 2754-2762.
Hurvitz S.A MS, Li W et al. A pooled analysis of trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2-positive (HER2+) metastatic breast cancer (mBC) with brain metastases (BMs) from DESTINYBreast (DB) -01, -02, and -03. 2023 ESMO 377O.
Bartsch R, Berghoff AS, Furtner J, et al. Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial. Nat Med. 2022. 28(9): 1840-1847.
Pérez-García JM, Vaz Batista M, Cortez P, et al. Trastuzumab deruxtecan in patients with central nervous system involvement from HER2-positive breast cancer: The DEBBRAH trial. Neuro Oncol. 2023. 25(1): 157-166.
Desmoulins I, Bellio H, Méjean N, Truntzer C, Ladoire S. Intracranial response of brain metastases in patients with HER2-amplified breast cancer treated with trastuzumab-deruxtecan after failure of tucatinib-based therapy. Eur J Cancer. 2023. 187: 161-163.
Im SA, Gennari A, Park YH, et al. Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, staging and treatment of patients with metastatic breast cancer. ESMO Open. 2023. 8(3): 101541.
Jacobson A. Trastuzumab Deruxtecan Improves Progression-Free Survival and Intracranial Response in Patients with HER2-Positive Metastatic Breast Cancer and Brain Metastases. Oncologist. 2022. 27(Suppl 1): S3-S4.
Montemurro F, Delaloge S, Barrios CH, et al. Trastuzumab emtansine (T-DM1) in patients with HER2-positive metastatic breast cancer and brain metastases: exploratory final analysis of cohort 1 from KAMILLA, a single-arm phase IIIb clinical trial(☆). Ann Oncol. 2020. 31(10): 1350-1358.

No competing interests reported.

Download PDF

Reviewers invited by journal
26 Sep, 2024
Editor assigned by journal
03 Sep, 2024
Submission checks completed at journal
03 Sep, 2024
First submitted to journal
03 Sep, 2024

You are reading this latest preprint version

Efficacy and safety of trastuzumab deruxtecan in HER2-positive breast cancer patients with brain metastases after failure of pyrotinib-based therapy

Status:

Version 1

Abstract

Figures

BACKGROUND

MATERIALS AND METHODS

Statistical analysis

RESULTS

DISCUSSION

CONCLUSIONS

Declarations

References

Additional Declarations

Status:

Version 1