Cybersecurity threats have become increasingly complex and adaptive, requiring dynamic defense mechanisms that can keep pace with evolving attack vectors. The proposed hybrid cryptographic defense framework integrates machine learning through Llama, an open-source large language model, with traditional cryptographic techniques, enabling real-time adjustments to encryption protocols based on identified threats. This approach offers a novel solution to the challenge of responding to unpredictable cyberattacks, significantly enhancing the system’s ability to detect and mitigate threats with minimal latency and high accuracy. Extensive experimentation demonstrated that the hybrid algorithm outperforms baseline methods in key areas, including resource utilization, false positive and negative rates, and adaptive encryption strength. The framework’s scalability and efficiency were also highlighted through its ability to handle large data volumes in real-time, making it a robust solution for cryptographic defense in modern network environments. Through combining machine learning with cryptographic operations, the system achieves a higher level of responsiveness and resilience, addressing critical gaps in current cybersecurity solutions.