Category
|
Term
|
P-value
|
FDR
|
Genes
|
Biology Process
|
GO:0006914~autophagy
|
1.53E-22
|
2.54E-19
|
GABARAPL2, GABARAPL1, BECN1, ITGB4, RGS19, FOXO1, SESN2, WIPI1, GABARAP, RAB33B, LAMP1, ATG4C, SQSTM1, SH3GLB1, ULK2, ATG4A, RB1CC1, RAB24, CTSD, MTOR, DRAM1
|
|
GO:0016236~macroautophagy
|
2.42E-17
|
4.01E-14
|
GABARAPL2, GABARAPL1, BECN1, PINK1, WIPI1, GABARAP, MAP1LC3A, SQSTM1, ULK1, NBR1, RB1CC1, MTOR, MLST8, ATG16L1, HDAC6
|
|
GO:0006915~apoptotic process
|
5.89E-15
|
9.75E-12
|
DLC1, FOXO1, NFKB1, PEA15, CASP3, CASP4, BAG1, SH3GLB1, SQSTM1, CXCR4, BCL2, CASP8, FAS, CASP1, CFLAR, BECN1, BIRC6, FADD, PRKCD, DDIT3, DAPK1, NCKAP1, BAX, MAPK3, PPP1R15A, DRAM1
|
|
GO:0000422~mitophagy
|
5.82E-13
|
9.64E-10
|
GABARAPL2, ATG9B, GABARAPL1, MAP1LC3A, ATG4C, SQSTM1, ATG4A, RB1CC1, PINK1, WIPI1
|
|
GO:0000045~autophagosome assembly
|
2.80E-12
|
4.64E-09
|
GABARAPL2, ATG9B, GABARAPL1, MAP1LC3A, ATG4C, BECN1, ATG4A, RB1CC1, ATG16L1, WIPI1
|
|
GO:0043066~negative regulation of apoptotic process
|
4.71E-12
|
7.80E-09
|
CFLAR, BECN1, SPHK1, BIRC6, FOXO1, NFKB1, SIRT1, CASP3, CDKN1A, CDKN1B, BAG1, HDAC1, SQSTM1, BCL2, VEGFA, BNIP3L, MAPK8, HSPA5, FAS, IKBKB, MYC
|
|
GO:0071456~cellular response to hypoxia
|
3.87E-10
|
6.42E-07
|
P4HB, EIF4EBP1, HIF1A, BCL2, VEGFA, BNIP3L, PINK1, FOXO3, MTOR, NFE2L2, SIRT1
|
|
GO:0016239~positive regulation of macroautophagy
|
4.52E-09
|
7.49E-06
|
HIF1A, ULK1, SQSTM1, BNIP3L, PINK1, SESN2, SIRT1
|
|
GO:0097192~extrinsic apoptotic signaling pathway in absence of ligand
|
5.70E-08
|
9.44E-05
|
BAK1, CASP3, BAX, BCL2, FADD, FAS, FOXO3
|
|
GO:0042981~regulation of apoptotic process
|
8.40E-08
|
1.39E-04
|
BID, CFLAR, PEA15, CASP4, BAX, CASP8, BNIP3L, FADD, FAS, CTSB, CASP1, DAPK1
|
|
GO:0008625~extrinsic apoptotic signaling pathway via death domain receptors
|
1.15E-07
|
1.90E-04
|
BID, BAX, BCL2, FADD, FAS, GABARAP, DAPK1
|
|
GO:0006468~protein phosphorylation
|
1.34E-07
|
2.21E-04
|
CCL2, ERBB2, BIRC6, PINK1, PRKCD, CAMKK2, DAPK1, IKBKE, SQSTM1, ULK1, MAPK3, ERN1, MAPK9, MAPK8, MTOR, IKBKB
|
|
GO:0007050~cell cycle arrest
|
2.24E-07
|
3.72E-04
|
CDKN1A, CDKN1B, TSC1, TSC2, ERN1, MLST8, MTOR, PPP1R15A, MYC, DDIT3
|
|
GO:0071260~cellular response to mechanical stimulus
|
2.74E-07
|
4.54E-04
|
BAK1, MAPK3, CASP8, NFKB1, MAPK8, FADD, FAS, CASP1
|
|
GO:1900034~regulation of cellular response to heat
|
4.01E-07
|
6.63E-04
|
HSP90AB1, BAG1, HSPB8, MAPK3, MLST8, DNAJB1, MTOR, SIRT1
|
|
GO:0006995~cellular response to nitrogen starvation
|
9.51E-07
|
1.58E-03
|
GABARAPL2, GABARAPL1, MAP1LC3A, BECN1, RB1CC1
|
|
GO:0043065~positive regulation of apoptotic process
|
2.52E-06
|
4.17E-03
|
BID, BAK1, SQSTM1, BAX, BNIP3L, FOXO1, MAPK8, FADD, FAS, FOXO3, SIRT1, ITGB1
|
|
GO:0097190~apoptotic signaling pathway
|
5.04E-06
|
8.35E-03
|
BAK1, CASP3, BAX, CASP8, FADD, FAS, DAPK1
|
|
GO:0001934~positive regulation of protein phosphorylation
|
1.39E-05
|
2.30E-02
|
SQSTM1, RB1CC1, ERBB2, MAPK3, VEGFA, PINK1, MTOR, SIRT1
|
|
GO:0010506~regulation of autophagy
|
1.40E-05
|
2.33E-02
|
ULK1, ULK2, CASP1, DRAM1, DAPK1, HDAC6
|
|
GO:0009636~response to toxic substance
|
1.44E-05
|
2.38E-02
|
FOS, CDKN1A, BAX, BCL2, MAPK3, FAS, HDAC6
|
|
GO:0050821~protein stabilization
|
2.16E-05
|
3.58E-02
|
HSP90AB1, LAMP1, LAMP2, CDKN1A, TSC1, PINK1, PRKCD, GAPDH
|
|
GO:0042149~cellular response to glucose starvation
|
2.93E-05
|
4.85E-02
|
BECN1, SH3GLB1, BCL2, HSPA5, NFE2L2
|
KEGG Pathway
|
hsa05200:Pathways in cancer
|
4.22E-14
|
5.09E-11
|
BID, HSP90AB1, GNAI3, ERBB2, FOXO1, NFKB1, ITGB1, FOS, CASP3, CXCR4, BCL2, CASP8, FAS, MYC, ITGA3, FADD, DAPK1, CDKN1A, CDKN1B, HIF1A, HDAC1, BAX, VEGFA, MAPK3, MAPK9, MAPK8, MTOR, IKBKB
|
|
hsa04141:Protein processing in endoplasmic reticulum
|
1.30E-10
|
1.57E-07
|
HSP90AB1, P4HB, CANX, EDEM1, DDIT3, BAK1, BAG1, BAX, BCL2, ERN1, MAPK9, MAPK8, HSPA5, NFE2L2, DNAJB1, PPP1R15A, SAR1A
|
|
hsa05161:Hepatitis B
|
1.48E-10
|
1.79E-07
|
NFKB1, FADD, IKBKE, FOS, CDKN1A, CASP3, CDKN1B, BAX, BCL2, CASP8, MAPK3, MAPK9, MAPK8, FAS, IKBKB, MYC
|
|
hsa04140:Regulation of autophagy
|
3.22E-10
|
3.89E-07
|
GABARAPL2, GABARAPL1, ATG4C, BECN1, ULK1, ULK2, ATG4A, ATG16L1, GABARAP
|
|
hsa05142:Chagas disease (American trypanosomiasis)
|
4.10E-08
|
4.95E-05
|
CFLAR, FOS, GNAI3, CCL2, MAPK3, CASP8, MAPK9, NFKB1, MAPK8, FADD, FAS, IKBKB
|
|
hsa04210:Apoptosis
|
4.68E-08
|
5.65E-05
|
BID, CFLAR, CASP3, BAX, BCL2, CASP8, NFKB1, FADD, FAS, IKBKB
|
|
hsa04668:TNF signaling pathway
|
5.53E-08
|
6.67E-05
|
CFLAR, FOS, CASP3, CCL2, MAPK3, CASP8, MAPK9, NFKB1, MAPK8, FADD, FAS, IKBKB
|
|
hsa05152:Tuberculosis
|
1.78E-07
|
2.14E-04
|
BID, SPHK1, FADD, NFKB1, LAMP1, CASP3, LAMP2, BAX, BCL2, CASP8, MAPK3, CTSD, MAPK9, MAPK8
|
|
hsa04066:HIF-1 signaling pathway
|
2.05E-07
|
2.48E-04
|
EIF4EBP1, CDKN1A, CDKN1B, HIF1A, BCL2, ERBB2, MAPK3, VEGFA, NFKB1, MTOR, GAPDH
|
|
hsa04621:NOD-like receptor signaling pathway
|
3.11E-07
|
3.76E-04
|
HSP90AB1, CCL2, MAPK3, CASP8, MAPK9, NFKB1, MAPK8, IKBKB, CASP1
|
|
hsa04150:mTOR signaling pathway
|
4.12E-07
|
4.97E-04
|
EIF4EBP1, TSC1, ULK1, ULK2, TSC2, MAPK3, MLST8, MTOR, IKBKB
|
|
hsa04068:FoxO signaling pathway
|
5.62E-07
|
6.79E-04
|
GABARAPL2, GABARAPL1, CDKN1A, CDKN1B, MAPK3, FOXO1, MAPK9, MAPK8, FOXO3, IKBKB, SIRT1, GABARAP
|
|
hsa04151:PI3K-Akt signaling pathway
|
6.37E-07
|
7.69E-04
|
HSP90AB1, ITGB4, NFKB1, ITGA3, FOXO3, ITGB1, EIF4EBP1, CDKN1A, CDKN1B, TSC1, BCL2, VEGFA, MAPK3, TSC2, MTOR, MLST8, IKBKB, MYC
|
|
hsa04012:ErbB signaling pathway
|
9.24E-07
|
1.12E-03
|
EIF4EBP1, CDKN1A, CDKN1B, NRG3, ERBB2, MAPK3, MAPK9, MAPK8, MTOR, MYC
|
|
hsa05215:Prostate cancer
|
1.02E-06
|
1.23E-03
|
HSP90AB1, CDKN1A, CDKN1B, BCL2, ERBB2, MAPK3, FOXO1, NFKB1, MTOR, IKBKB
|
|
hsa05133:Pertussis
|
3.06E-06
|
3.70E-03
|
FOS, CASP3, GNAI3, MAPK3, MAPK9, NFKB1, MAPK8, CASP1, ITGB1
|
|
hsa05145:Toxoplasmosis
|
6.66E-06
|
8.04E-03
|
CASP3, GNAI3, BCL2, MAPK3, CASP8, MAPK9, NFKB1, MAPK8, IKBKB, ITGB1
|
|
hsa05210:Colorectal cancer
|
8.99E-06
|
1.09E-02
|
FOS, CASP3, BAX, BCL2, MAPK3, MAPK9, MAPK8, MYC
|
|
hsa04932:Non-alcoholic fatty liver disease (NAFLD)
|
1.32E-05
|
1.60E-02
|
BID, CASP3, BAX, CASP8, ERN1, MAPK9, NFKB1, MAPK8, FAS, IKBKB, DDIT3
|
|
hsa04071:Sphingolipid signaling pathway
|
1.36E-05
|
1.64E-02
|
BID, GNAI3, BAX, BCL2, MAPK3, SPHK1, MAPK9, CTSD, NFKB1, MAPK8
|
|
hsa04115:p53 signaling pathway
|
1.51E-05
|
1.83E-02
|
BID, CDKN1A, CASP3, BAX, TSC2, CASP8, FAS, SESN2
|
|
hsa05231:Choline metabolism in cancer
|
2.84E-05
|
3.43E-02
|
FOS, EIF4EBP1, HIF1A, TSC1, TSC2, MAPK3, MAPK9, MAPK8, MTOR
|
|
hsa04620:Toll-like receptor signaling pathway
|
4.03E-05
|
4.87E-02
|
IKBKE, FOS, MAPK3, CASP8, MAPK9, NFKB1, MAPK8, FADD, IKBKB
|
GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.
|