Blockchain technology is a perfect way to integrate with the Internet of Things. It improves interoperability by building a more reliable system that enhances security and privacy and can be scalable with modern-era technology. However, the problem in the current blockchain system is the susceptibility of traditional cryptographic protocols to quantum attacks with the rapid achievement of large quantum machines that were used as recent computers. The NIST has supported research trends in post-quantum cryptography, leading to research challenges in using post-quantum cryptography to build blockchain-based applications for IoT devices. It’s likely to use relatively small public and secret keys that were found in the third evaluation round of the post-quantum standardization project from the NIST such as the supersingular isogeny key encapsulation (SIKE) protocol. However, the SIKE protocol faces a challenge in latency output, which encourages researchers to devote efforts and challenges to efficiently implement SIKE for many real-world applications. The main direction for this research is to achieve its objective, which was to rebuild a secure blockchain-based network to integrate resource-constrained IoT ecosystems by adding improvements to the cryptographic techniques used, such as SIKE, which has excellent resistance to brute force attacks and other types of attacks like the Whitewashing attack. Our FPGA implementation demonstrates a substantial performance improvement in the key processing time. The study is built in VIRTEX-6 XC6VLX760 and gives the results of 24 ms key p434 generation, 72 ms p434 encapsulation, and 73 ms p434 decapsulation inside SIKEp434.