Ethics approval and consent to participate
Ethics approval of this study was obtained from China Medical University and the Institutional Review Boards (IRB) of the collaborating hospitals (CMUH104-REC2-115). The written informed consent was obtained from all individual participants included in the study.
Consent to publish
Not applicable
Availability of data and materials
The datasets generated and/or analyzed during the current study are not publicly available due to the restrictions of the local ethics committee and institutional data security and privacy policies. The data access request needs institutional and ethics committee’s approval.
Competing interests
The author(s) confirm that this article content has no conflicts of interest.
Funding
CYH is supported in part by Taiwan Ministry of Health and Welfare Clinical Trial Center (MOHW109-TDU-B-212-114004), MOST Clinical Trial Consortium for Stroke (MOST 108-2321-B-039-003-), Tseng-Lien Lin Foundation, Taichung, Taiwan. The funders had no role in the study design, data collection, analysis, or interpretation.
Authors' Contributions
PLC, WLC, PYY, CYW, MJT, YS, CHL, JTL, TCL, LML, MCL, CLL, and HKW designed research; CLL, HJC, YCL, CCW, CHT, and HKW analyzed data; HKW, and CYH wrote the paper.
Acknowledgements
Not Applicable
Authors' Information
Affiliations
School of Medicine, I-Shou University, Kaohsiung, Taiwan
Cheng-Loong Liang, Han-Jung Chen, Yi-Che Lee, Cheng-Chun Wu,
Hao-Kuang Wang
Division of Neurology, China Medical University Hospital, Taichung, Taiwan
Chon-Haw Tsai
Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan
Po-Lin Chen
Department of Neurology, Show Chwan Memorial Hospital, Changhua County, Taiwan
Wei-Lun Chang
Department of Neurology, St. Martin De Porres Hospital, Chiayi, Taiwan
Po-Yen Yeh
Department of Neurology, Chang Bing Show Chwan Memorial Hospital, Changhua County, Taiwan
Cheng-Yu Wei
Department of Neurology, Tainan Municipal An-Nan Hospital-China Medical University, Tainan, Taiwan
Ming-Jun Tsai
Department of Neurology, En Chu Kong Hospital, Xinbei City, Taiwan
Yu Sun
Department of Neurology, Lin Shin Hospital, Taichung, Taiwan
Chih-Hao Lin
Department of Neurology, Tri-Service General Hospital, Taipei, Taiwan
Jiunn-Tay Lee
Department of Neurology, Cheng Hsin General Hospital, Taipei, Taiwan
Ta-Chang Lai
Department of Neurology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
Li-Ming Lien
Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
Mei-Chen Lin, Cheng-Li Lin
Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
Chung Y. Hsu