1.1 Study design
A retrospective cohort study was conducted in the Department of Family planning division, Chongqing Health Center For Women and Children, with approval of the institutional ethics committee. 1067 patients were selected who terminated pregnancy between January 1st 2018 to May 31st 2019 in Chongqing Health Center For Women and Children. Data were collected from medical record of the patients. Collected data including the age, gestational age, postoperative ultrasound report and diameter of the residual .
Exclusion criteria
Preoperative color ultrasound indicated uterine malformations, uterine fibroids, adenomyoma and uterine septum; Patients who are not pregnant for the first time. Patients with internal diseases(Including diabetes, hypertension, thyroid diseases, endocrine diseases and cardiovascular disease). We excluded participants for any of the following reasons: allergy or contraindication of mifepristone and misoprostol and with history of smoking or drinking.
Inclusion criteria
All the patients were pregnant for the first time, aged from 18 to 35, gestational age from 6 to 10 weeks, no abnormalities in routine examination of leucorrhea, blood routine, immunity and electrocardiogram before operation. Take mifepristone and misoprostol In test group,467 people were included. Take misoprostol alone In controlled group, including 600 people. The average age of test group is 20.5±1.21(year)༌the controlled group is 21.2±1.37(year)(P>0.05). Gestational age in test group is 53.6±5.2 days༌the controlled group is 52.4±5.4 days (P>0.05). There were no statistical difference between the two groups in average age and gestatinal age .(Table 1)
Table 1
Comparison of characteristics on test group and control group
Groups
|
Cases(n)
|
Average age(Year)
|
Gestational age(Day)
|
Test Group
(mifepristone + misoprostol)
|
467
|
20.5±1.21
|
53.6±5.2
|
Controlled Group
(misoprostol)
|
600
|
21.2±1.37
P>0.05
|
52.4±5.4
P>0.05
|
1.2 Methods
The test group was given 150 mg mifepristone the day before operation ,75 mg bid orally, 600 mg misoprostol was taken orally half an hour before operation, According to directions the Misoprostol is absorbed rapidly by oral administration and can be completely absorbed after 1.5 hours. The controlled group received oral misoprostol 600 mg only half an hour before operation. Two attending physicians performed all operations and patients were randomly assigned. All operations were performed under intravenous anaesthesia by using propofol.
1.3 Statistical indicators
All patients take preoperative ultrasonography to evaluate the gestational age, Ultrasound was performed 7 to 10 days after abortion to check if there was any residual tissue in uterine cavity. The size of residual tissue in patients was also counted.
1.4 Statistical analysis
Statistical analysis was performed using SPSS: package 22 edition. To test the statistical signifcance, the χ2 test or T test is used. T-test is used for comparison of measurement data, χ2 test is used for counting data. P