4.1 Serum NO
The difference between GO + MSC group and blank group in group A was statistically significant (P < 0.01), and there was no significant difference between MSC group, GO group and blank group (P > 0.05). The difference was not statistically significant (P > 0.05). The difference between GO + MSC group and blank group in group B was statistically significant (P < 0.01), the difference between MSC group, GO group and blank group was statistically significant (P < 0.05). The difference between GO + MSC group and MSC group was It has statistical significance (P < 0.05). Compared between groups, the difference between GO + MSC group, MSC group and GO group was not statistically significant (P > 0.05), and the difference between blank group was statistically significant (P < 0.05) (Table 1).
Table 1
Serum NO results after treatment(±s,ng/ml)
Group | Blank | GO | MSC | GO + MSC |
Group A | 22.097 ± 0.352 | 21.436 ± 0.0311) | 21.020 ± 0.0262) | 17.624 ± 0.1273) |
Group B | 23.662 ± 0.056 | 20.544 ± 0.0854) | 19.424 ± 0.0465) | 17.799 ± 0.0496) |
P value | 0.029 | 0.430 | 0.254 | 0.725 |
4.2 Serum COL-II
Within group comparison, the difference between GO + MSC group, MSC group and blank group in group A was statistically significant (P < 0.01), and the difference between GO group and blank group was not statistically significant (P > 0.05); GO + MSC The difference between the group and the MSC group was statistically significant (P < 0.01). In group B, the difference between GO + MSC group and blank group was statistically significant (P < 0.01), the difference between MSC group, GO group and blank group was not statistically significant (P > 0.05); GO + MSC group and MSC group. The difference was statistically significant (P < 0.01).
Compared between groups, the difference between GO + MSC group and MSC group was statistically significant (P < 0.01), and the difference between GO group and blank group was not statistically significant (P > 0.05) (Table 2).
Table 2
Serum COL-II results after treatment(±s,ng/ml)
Group | Blank | GO | MSC | GO + MSC |
Group A | 13.475 ± 0.342 | 14.127 ± 0.1021) | 15.589 ± 0.0632) | 19.372 ± 0.0633) |
Group B | 12.253 ± 0.147 | 13.644 ± 0.0284) | 14.429 ± 0.0925) | 16.257 ± 0.4166) |
P value | 0.315 | 0.249 | 0.009 | 0.000 |
4.3 Serum GAG
In group A, the difference between GO + MSC group and blank group was statistically significant (P < 0.01), the difference between MSC group and blank group was statistically significant (P < 0.05), and the difference between GO group and blank group was not statistically significant. Significance (P > 0.05). The difference between GO + MSC group and MSC group was statistically significant (P < 0.01). In group B, the difference between GO + MSC group, MSC group and blank group was statistically significant (P < 0.01), the difference between GO group and blank group was statistically significant (P < 0.05); comparison between GO + MSC group and MSC group. The difference was statistically significant (P < 0.05).
Compared between groups, the difference between the blank group and the GO + MSC group was statistically significant (P < 0.01), and the difference between the MSC group and the GO group was not statistically significant (P > 0.05) (Table 3).
Table 3
Serum GAG results after treatment(±s,ng/ml)
Group | Blank | GO | MSC | GO + MSC |
Group A | 23.832 ± 0.891 | 26.342 ± 1.0421) | 29.022 ± 0.9732) | 37.439 ± 2.1553) |
Group B | 18.709 ± 0.552 | 22.689 ± 0.6414) | 24.028 ± 0.6755) | 26.554 ± 0.4506) |
P Value | 0.002 | 0.096 | 0.051 | 0.000 |
4.4 Serum IL-6.
In group A, the difference between GO + MSC group, MSC group, GO group and blank group was statistically significant (P < 0.01); the difference between GO + MSC group and MSC group was statistically significant (P < 0.01). In group B, the difference between GO + MSC group, MSC group, GO group and blank group was statistically significant (P < 0.01); the difference between GO + MSC group and MSC group was statistically significant (P < 0.05).
Compared between groups, the difference between GO + MSC group was statistically significant (P < 0.01), the difference between blank group was statistically significant (P < 0.05), the difference between MSC group and GO group was not statistically significant (P > 0.05) (Table 4).
Table 4
Result of serum IL-6 after treatment(±s,ng/ml)
Group | Blank | GO | MSC | GO + MSC |
Group A | 16.082 ± 0.323 | 10.957 ± 0.3431) | 9.668 ± 0.1942) | 7.426 ± 0.2943) |
Group B | 18.367 ± 0.861 | 10.002 ± 0.1914) | 9.506 ± 0.1235) | 8.680 ± 0.2426) |
P Value | 0.024 | 0.169 | 0.565 | 0.009 |
4.5 Serum TNF-α
In group A, the difference between GO + MSC group, MSC group, GO group and blank group was statistically significant (P < 0.01); the difference between GO + MSC group and MSC group was statistically significant (P < 0.01). In group B, the difference between GO + MSC group, MSC group, GO group and blank group was statistically significant (P < 0.01); the difference between GO + MSC group and MSC group was statistically significant (P < 0.05).
Compared between groups, the difference between GO + MSC group was statistically significant (P < 0.01), the difference between blank group was statistically significant (P < 0.05), the difference between MSC group and GO group was not statistically significant (P > 0.05) (Table 5).
Table 5
Result of serum TNF-α after treatment(±s,ng/ml)
Group | Blank | GO | MSC | GO + MSC |
Group A | 9.466 ± 0.177 | 8.447 ± 0.1131) | 6.109 ± 0.0442) | 5.139 ± 0.1833) |
Group B | 10.013 ± 0.197 | 8.891 ± 0.1884) | 6.856 ± 0.1605) | 6.210 ± 0.0586) |
PValue | 0.037 | 0.087 | 0.146 | 0.006 |