Crucial for the competitiveness of small and medium-sized enterprises on global markets is that companies not only use AI to concentrate on the efficiency and thus improvement of internal processes but also on the effectiveness, i.e. the development of (service) business models. In this context more and more companies are realising the potentials of AI, but they are lacking the knowledge of how they could integrate it into their existing business. In order to systematically support the effective and efficient development of AI-based (service) business models for small and medium-sized enterprises, this article is targeted at the development of a design framework for the implementation of AI-based service business models for small and medium-sized enterprises.