Brief Communication
Accurate genotyping of single cells with Octopus
https://doi.org/10.21203/rs.3.rs-583831/v1
This work is licensed under a CC BY 4.0 License
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We describe an extension to our variant calling tool, Octopus (https://github.com/luntergroup/octopus), for single-cell DNA sequencing data. Octopus jointly genotypes cells from a lineage, accounting for amplification stochasticity and sequencing error with a haplotype-based Bayesian model. Octopus is considerably more accurate at genotyping single cells than existing methods.
Variant Calling Tool
Amplification Stochasticity
Sequencing Error
Haplotype-based Bayesian Model
There is NO Competing Interest.
Supplementary Information
Supplementary Table 1
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