Ethics approval and consent to participate
All subjects were informed about the experimental procedures and gave their written consent. The experimental protocol conformed to the standards set by the Declaration of Helsinki and was approved by the local Ethic Committee (CPP Sud-Ouest Outre-Mer I, France) and French Health Authorities (n° ID RCB: 2014-A 00904-43).
Consent for publication
The authors affirm that human research participants provided informed consent for
data collected being used for publication, and a number of publications from this DI study protocol have since been published. All authors have read and approved the final manuscript for publication.
Availability of data and material
The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
Competing interests
All other authors report no financial, professional or personal conflicts of interest relating to this publication.
Funding
This dry immersion protocol was supported by CNES (DAR CNES N° 2018 – 4800000970). R.P.M. acknowledges the funding support of Science Foundation Ireland (11/TIDA/B1927), Health Research Board of Ireland (HRA/2009/122), Enterprise Ireland and the European Regional Development Fund (ERDF) under Ireland's European Structural and Investment Funds programmes (PC-2009-0311, INV/13000/001/2015, IP 2015 0399Y, IP 2015 0418 & IP 2017 0587). L.T. was in part supported by an Irish Research Council for Science, Engineering & Technology (IRCSET) EMBARK Postgraduate Scholarship 2012-2015 (RS/2012/2499). RPM is a management committee member of the EU H2020 COST actions- CM1406 & CA18127.
Authors contributions
All authors approved the final version to be published. Conceptualization: Nastassia Navasiolava, Marie-Pierre Bareille, Guillemette Gauquelin-Koch, Françoise Larcher, Gerardene Meade-Murphy, Claude Gharib, Marc-Antoine Custaud, Ronan P. Murphy; Data curation: Laura Twomey, Nastassia Navasiolava, Adrien Robin, Marie-Pierre Bareille, Guillemette Gauquelin-Koch, Arnaud Beck, Françoise Larcher, Patricia B. Maguire, Marc-Antoine Custaud, Ronan P. Murphy; Formal analysis: Laura Twomey, Nastassia Navasiolava, Adrien Robin, Marie-Pierre Bareille, Guillemette Gauquelin-Koch, Arnaud Beck, Françoise Larcher, Gerardene Meade-Murphy, Sinead Sheridan, Patricia B. Maguire, Michael Harrison, Bernard Degryse, Niall M. Moyna, Claude Gharib, Marc-Antoine Custaud, Ronan P. Murphy; Funding acquisition: Laura Twomey, Nastassia Navasiolava, Françoise Larcher, Claude Gharib, Marc-Antoine Custaud, Ronan P. Murphy; Investigation: Laura Twomey, Nastassia Navasiolava, Adrien Robin, Marie-Pierre Bareille, Guillemette Gauquelin-Koch, Arnaud Beck, Françoise Larcher, Patricia B. Maguire, Marc-Antoine Custaud, Ronan P. Murphy; Methodology: Laura Twomey, Nastassia Navasiolava, Adrien Robin, Marie-Pierre Bareille, Guillemette Gauquelin-Koch, Arnaud Beck, Françoise Larcher, Gerardene Meade-Murphy, Sinead Sheridan, Patricia B. Maguire, Michael Harrison, Bernard Degryse, Niall M. Moyna, Claude Gharib, Marc-Antoine Custaud, Ronan P. Murphy; Project administration: Nastassia Navasiolava, Marie-Pierre Bareille, Guillemette Gauquelin-Koch, Arnaud Beck, Françoise Larcher, Claude Gharib, Marc-Antoine Custaud, Ronan P. Murphy; Resources: Marie-Pierre Bareille, Guillemette Gauquelin-Koch, Arnaud Beck, Françoise Larcher, Patricia B. Maguire, Claude Gharib, Marc-Antoine Custaud, Ronan P. Murphy; Supervision: Nastassia Navasiolava, Marie-Pierre Bareille, Guillemette Gauquelin-Koch, Arnaud Beck, Françoise Larcher, Patricia B. Maguire, Claude Gharib, Marc-Antoine Custaud, Ronan P. Murphy; Validation: Laura Twomey, Nastassia Navasiolava, Adrien Robin, Marie-Pierre Bareille, Guillemette Gauquelin-Koch, Arnaud Beck, Françoise Larcher, Gerardene Meade-Murphy, Sinead Sheridan, Patricia B. Maguire, Michael Harrison, Bernard Degryse, Niall M. Moyna, Claude Gharib, Marc-Antoine Custaud, Ronan P. Murphy; Visualization: Nastassia Navasiolava, Adrien Robin, Marc-Antoine Custaud, Ronan P. Murphy; Writing – original draft: Laura Twomey, Nastassia Navasiolava, Adrien Robin, Marc-Antoine Custaud, Ronan P. Murphy; Writing – review & editing: All authors.
Acknowledgements
We thank the volunteers and the staff of MEDES (Toulouse, France) for their participation in this study.
Authors' information
Laura Twomey1,2*, Nastassia Navasiolava3*, Adrien Robin3, Marie-Pierre Bareille4, Guillemette Gauquelin-Koch5, Arnaud Beck4, Françoise Larcher6, Gerardene Meade-Murphy7, Sinead Sheridan8, Patricia B. Maguire9, Michael Harrison10, Bernard Degryse2,12, Niall M. Moyna11,12, Claude Gharib13, Marc-Antoine Custaud3, Ronan P. Murphy2,12
1 Technological University Dublin, Ireland
2 Cell & Molecular Physiology Group, School of Health & Human Performance, Dublin City University, Glasnevin, Dublin 9, Ireland
3 Univ Angers, CHU Angers, CRC, Inserm, CNRS, MITOVASC, SFR ICAT, F-49000 Angers, France
4 MEDES, Toulouse, France
5 Centre National d'Études Spatiales (CNES), Paris, France
6 CHU Angers, Laboratoire de Biochimie, Univ Angers, F-49000 Angers, France
7 Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland
8 Department of Sports Science & Physical Education, The Chinese University of Hong Kong
9 Conway-SPHERE Research Group, Conway Institute, University College Dublin, Dublin, Ireland
10 Department of Sport and Exercise Science, Waterford Institute of Technology, Cork Road, Waterford, Ireland
11 Vascular Physiology and Clinical Exercise Medicine Group, School of Health & Human Performance, DCU, Glasnevin, D9, Ireland
12 Centre for Preventive Medicine, DCU, Glasnevin, D9, Ireland
13 Institut NeuroMyoGène, Faculté de Médecine Lyon-Est, Université de Lyon, Lyon, France