In this paper, we study the effect of winglet Toe & Twist angle on the wing of the aircraft aerodynamics performances and how to improve it, we analyze the aerodynamics properties of the wing with winglets with Cant angle 60o and winglet span = 3.5 m, we test wings with different toe angles (+10o, +5o, 0o, -5o, and -10o) and twisted angles (+5o, 0o, and +5o) and all model are tested for four Angle of attack AOA (0o, 3o, 6o, and 9o). Then calculate the value of L/D to decide which wing has a high value of lift and lower drag. All models of a wing (sixty models) are drawn for 3D using the SOLIDWORKS program where we used Boeing 737-800 wing dimensions. Then all models of a wing were analyzed using ANSYS FLUENT.