In this research CoFe2O4@CMC/ HZSM-5 synthesized in the presence of Carboxymethylcellulose as a biopolymer in the green conditions as a new nanomagnetic adsorbent for metronidazole removal from aqueous media. Physical and chemical structure of adsorbent was investigated by FTIR, FESEM, EDS, Mapping, TEM, XRD, VSM, BET and TGA techniques. The results indicated that 94% of the metronidazole concentration removed by CoFe2O4@CMC/HZSM-5 in the optimal conditions including pH 6, temperature 20oC, metronidazole concentration 50 mg/L, contact time 60 min and adsorbent dose 2 g/L. The resulting data from adsorption experimental experiments had better correlated with the Freundlich isotherm and pseudo-second order kinetic. Also, the thermodynamic study demonstrated that the adsorption process was an endothermic process and had a physical mechanism. As well as, the achieved findings demonstrated that following six adsorption runs, the adsorbent chemical structure had no change and the nanomagnetic adsorbent efficiency in the removal process had a slight decrease. CoFe2O4@CMC/HZSM-5 magnetic nanocomposite had effective adsorption capacity for metronidazole removal.