This paper gives insights about examinations of plasmonic nanoparticles and particularly gold nanostar as sign enhancer and contrast agent for clinical imaging and the optical properties of (NPs) of different volume and morphology and the encompassing medium were stood out from affirm that the gold nanostars are the best shape that can Scatter the light, thusly obtaining better and all the most clear clinical imaging. Stars formed gold nanoparticles have a greater surface comparative with its volume and contact surface cross section than spherical and rods shaped nanoparticles, and accordingly act even more firmly as a radiation enhancer. At that point the wavelength of the (SPR) is in the body tissues transparence window, the laser can impact gold nanostars more profound inside the human body. Mathematical outcomes exhibit that the gold nanostar has more powerful Scattering cross section conversely with sphere and rod shaped gold nanoparticles. The largest nanostar displayed better contrast properties for imaging applications, for instance, confocal microscopy and optical coherence tomography.