Stroke
|
Cohort
|
1368
|
2662
|
2849
|
2787
|
2667
|
1720
|
2451
|
No. of deaths
|
14 (0.010)
|
28 (0.011)
|
28 (0.010)
|
25 (0.009)
|
39 (0.015)
|
37 (0.022)
|
51 (0.021)
|
Model 1
(HR, 95% CI)
|
1.22 (0.64–2.35), P = 0.55
|
1.19 (0.70–2.05), P = 0.52
|
1.13 (0.66–1.94), P = 0.66
|
1.00
|
1.63 (0.99–2.69), P = 0.06
|
2.39 (1.44–3.97), P = 0.001
|
2.34 (1.45–3.77), P = 0.001
|
Model 2
(HR, 95% CI)
|
1.86 (0.96–3.60), P = 0.07
|
1.69 (0.98–2.92), P = 0.06
|
1.41 (0.82–2.42), P = 0.22
|
1.00
|
1.41 (0.85–2.34), P = 0.18
|
1.83 (1.10–3.05), P = 0.02
|
1.66 (1.03–2.70), P = 0.04
|
Order cohort$
|
261
|
511
|
669
|
898
|
887
|
677
|
1035
|
No. of deaths
|
12 (0.046)
|
16 (0.031)
|
20 (0.030)
|
14 (0.016)
|
27 (0.030)
|
28 (0.042)
|
47 (0.045)
|
Model 1
(HR, 95% CI)
|
3.01 (1.39–6.50), P = 0.005
|
1.96 (0.96–4.03), P = 0.07
|
1.90 (0.96–3.77), P = 0.07
|
1.00
|
1.92 (1.01–3.66), P = 0.05
|
2.63 (1.39-5.00), P = 0.003
|
3.04 (1.67–5.51), P < 0.001
|
Model 2
(HR, 95% CI)
|
3.68 (1.68–8.05), P = 0.001
|
2.11 (1.02–4.34), P = 0.04
|
2.07 (1.04–4.11), P = 0.04
|
1.00
|
1.69 (0.89–3.24), P = 0.11
|
2.30 (1.20–4.39), P = 0.01
|
2.50 (1.37–4.57), P = 0.003
|
Younger cohort&
|
1107
|
2151
|
2180
|
1889
|
1780
|
1043
|
1416
|
No. of deaths
|
2 (0.002)
|
12 (0.006)
|
8 (0.004)
|
11 (0.006)
|
12 (0.007)
|
9 (0.009)
|
4 (0.003)
|
Model 1
(HR, 95% CI)
|
0.33 (0.07–1.50), P = 0.15
|
0.97 (0.43–2.21), P = 0.95
|
0.65 (0.26–1.63), P = 0.36
|
1.00
|
1.17 (0.52–2.65), P = 0.71
|
1.49 (0.62–3.59), P = 0.38
|
0.48 (0.15–1.51), P = 0.21
|
Model 2
(HR, 95% CI)
|
0.37 (0.08–1.69), P = 0.20
|
1.14 (0.50–2.60), P = 0.76
|
0.70 (0.28–1.76), P = 0.45
|
1.00
|
1.14 (0.50–2.61), P = 0.75
|
1.35 (0.56–3.30), P = 0.51
|
0.42 (0.13–1.34), P = 0.14
|
Ischaemic stroke
|
Cohort
|
1357
|
2651
|
2829
|
2774
|
2640
|
1698
|
2428
|
No. of deaths
|
3 (0.002)
|
17 (0.006)
|
8 (0.003)
|
12 (0.004)
|
12 (0.004)
|
15 (0.009)
|
28 (0.012)
|
Model 1
(HR, 95% CI)
|
0.55 (0.15–1.94), P = 0.35
|
1.51 (0.72–3.16), P = 0.28
|
0.67 (0.28–1.65), P = 0.39
|
1.00
|
1.05 (0.47–2.33), P = 0.91
|
2.03 (0.95–4.33), P = 0.07
|
2.68 (1.37–5.28), P = 0.004
|
Model 2
(HR, 95% CI)
|
0.78 (0.22–2.79), P = 0.70
|
2.10 (0.99–4.45),
P = 0.05
|
0.80 (0.32–1.96), P = 0.62
|
1.00
|
0.93 (0.42–2.07), P = 0.86
|
1.58 (0.74–3.40), P = 0.24
|
2.01 (1.01–3.99), P = 0.04
|
Order cohort$
|
251
|
504
|
655
|
891
|
868
|
661
|
1014
|
No. of deaths
|
2 (0.008)
|
9 (0.018)
|
6 (0.009)
|
7 (0.008)
|
8 (0.009)
|
12 (0.018)
|
26 (0.026)
|
Model 1
(HR, 95% CI)
|
1.02 (0.21–4.89), P = 0.98
|
2.21 (0.82–5.95), P = 0.12
|
1.15 (0.39–3.43), P = 0.80
|
1.00
|
1.15 (0.42–3.16), P = 0.79
|
2.29 (0.90–5.80, P = 0.08
|
3.40 (1.48–7.84), P = 0.004
|
Model 2
(HR, 95% CI)
|
1.19 (0.24–5.81), P = 0.83
|
2.40 (0.88–6.51), P = 0.09
|
1.21 (0.40–3.64), P = 0.73
|
1.00
|
1.03 (0.37–2.86), P = 0.95
|
2.01 (0.78–5.14), P = 0.15
|
2.93 (1.26–6.82), P = 0.01
|
Younger cohort&
|
1106
|
2147
|
2174
|
1883
|
1772
|
1037
|
1414
|
No. of deaths
|
1 (0.001)
|
8 (0.004)
|
2 (0.001)
|
5 (0.003)
|
4 (0.002)
|
3 (0.003)
|
2 (0.001)
|
Model 1
(HR, 95% CI)
|
0.35 (0.04–3.03), P = 0.34
|
1.42 (0.46–4.33), P = 0.54
|
0.35 (0.07–1.82), P = 0.21
|
1.00
|
0.86 (0.23–3.19), P = 0.82
|
1.09 (0.26–4.56), P = 0.91
|
0.53 (0.10–2.73), P = 0.45
|
Model 2
(HR, 95% CI)
|
0.38 (0.04–3.33), P = 0.39
|
1.61 (0.52–5.02), P = 0.41
|
0.36 (0.07–1.86), P = 0.22
|
1.00
|
0.82 (0.22–3.07), P = 0.75
|
1.01 (0.24–4.29), P = 0.98
|
0.49 (0.09–2.57), P = 0.40
|
Haemorrhagic stroke
|
Cohort
|
1361
|
2638
|
2834
|
2770
|
2648
|
1700
|
2413
|
No. of deaths
|
7 (0.005)
|
4 (0.002)
|
13 (0.005)
|
8 (0.003)
|
20 (0.008)
|
17 (0.01)
|
13 (0.005)
|
Model 1
(HR, 95% CI)
|
1.92 (0.70–5.29, P = 0.21
|
0.54(0.16–1.78), P = 0.31
|
1.64 (0.68–3.96), P = 0.27
|
1.00
|
2.61 (1.15–5.93), P = 0.02
|
3.44 (1.49–7.98), P = 0.004
|
1.87 (0.77–4.50), P = 0.17
|
Model 2
(HR, 95% CI)
|
2.75 (0.99–7.69), P = 0.05
|
0.72 (0.22–2.40), P = 0.59
|
2.01 (0.83–4.88), P = 0.12
|
1.00
|
2.24 (0.98–5.10), P = 0.06
|
2.65 (1.14–6.18), P = 0.02
|
1.32 (0.54–3.21), P = 0.54
|
Order cohort$
|
255
|
497
|
658
|
888
|
875
|
660
|
1000
|
No. of deaths
|
6 (0.024)
|
2 (0.004)
|
9 (0.014)
|
4 (0.004)
|
15 (0.017)
|
11 (0.017)
|
12 (0.012)
|
Model 1
(HR, 95% CI)
|
5.31(1.50-18.83), P = 0.01
|
0.87 (0.16–4.77), P = 0.88
|
3.01 (0.93–9.78), P = 0.07
|
1.00
|
3.74(1.24–11.28), P = 0.02
|
3.65(1.16–11.46), P = 0.03
|
2.73 (0.88–8.45), P = 0.08
|
Model 2
(HR, 95% CI)
|
6.16 (1.69–22.40), P = 0.006
|
0.84 (0.15–4.61), P = 0.84
|
3.28(1.00-10.75), P = 0.05
|
1.00
|
3.26 (1.08–9.89), P = 0.04
|
3.09 (0.98–9.78), P = 0.06
|
2.16 (0.69–6.76), P = 0.18
|
Younger cohort&
|
1106
|
2141
|
2176
|
1882
|
1773
|
1040
|
1413
|
No. of deaths
|
1 (0.001)
|
2 (0.001)
|
4 (0.002)
|
4 (0.002)
|
5 (0.003)
|
6 (0.006)
|
1 (0.001)
|
Model 1
(HR, 95% CI)
|
0.47 (0.05–4.20), P = 0.50
|
0.45 (0.08–2.46), P = 0.36
|
0.92 (0.23–3.66), P = 0.90
|
1.00
|
1.34 (0.36–4.98), P = 0.67
|
2.74 (0.77–9.70), P = 0.12
|
0.33 (0.04–2.98), P = 0.33
|
Model 2
(HR, 95% CI)
|
0.48 (0.05–4.37), P = 0.52
|
0.48 (0.09–2.68), P = 0.41
|
0.99 (0.25–4.03), P = 0.99
|
1.00
|
1.44 (0.38–5.40), P = 0.59
|
2.82 (0.78–10.20), P = 0.11
|
0.35 (0.04–3.14), P = 0.34
|