Propose of the experimental study a found a sufficient model to predict the ambient temperature over the area of Biskra, Algeria, taking into account new air pollution factors such as CO, CO2, O3, and NO2. We found that the effect of air pollution, astronomical and meteorological elements have obvious in the ambient temperature, and be behavior, according to regional characteristics. Using the fitting of the experimental data for establishing a set of prediction data sets of pollutants, astronomical, and meteorological elements at the University of Biskra, Algeria. We recorded the highest NO2 value in March at an estimated value of 1.6.1015 (mole/cm), where the ambient temperature rate is low. The mathematical model obtained gives a satisfactory results, because they were substantially identical and without almost any error with the experimental data. Finally, the latter can be used by engineers and especially those who work in the environmental field which is very sensitive to temperature variation and it can influence the health of the human being.