Newtonian inertia has initiated science centuries ago and dictates modern society with isolated logic systems. The hidden premise of this system is rigid existence in an isolated environment that defies any internal motion. Later presented equivalent principle and the T-symmetry reversible processes also follow such a notion. However, bio-inertia originates from the blind spots of this system. (Surface tension inversion as the most universal interaction is sacrificed for methodological isolation/test purposes and then neglected by science.) We define and experiment bio-inertia as “parameter-against-gravity-internal-motion”, revealing inversion time or memory which maintains bio-systems in an entropy-controlled state originates from topological event inversion superposition of bio quantum paths, conventional quantum collapse instancy is then extended to lifespan. Bio quantum path duality physically equivalent inversion time between Planck regions and surface tension regions by a string or surface tension topological property equation drives biological functioning and evolution, which is generalized as the Basic Law of evolution. The topological copy quiddity of life is then unveiled.