Background: Sepsis is a global medical problem and consistently the leading cause of death. Quick identification can help clinicians to determine the appropriate antibiotic treatment and reduce mortality. Sepsityper Kit is fast and easy-to-operate method. However, the studies on its performance is inconsistent. Thus, in other to fill the gap, we conducted data analysis to evaluate the effectiveness of the Sepsityper kit on pathogen identification.
Methods: Relevant literature were searched in PubMed, Embase, Cochrane Library, and Web of Science. The correct identification rate of gram-positive bacteria, gram-negative bacteria, and fungi at the species and genus level were analyzed. Stata 12.0 was used to explore the publication bias of the included literature.
Results: 30 articles were included. The diagnostic performance in gram-negative bacteria genus level was 96% (P = 0.000; I 2 = 80.9%), in gram-negative bacteria species level was 88% (P = 0.000; I 2 = 89.2%), in gram-positive bacteria genus level was 85% (P = 0.000; I 2 = 94.0%), in gram-positive bacteria species level was 65% (P = 0.000; I 2 = 89.2%), in genus level of fungi was 85% (P = 0.000; I 2 = 90.0%), and in the of species level of fungi was 59% (P = 0.000; I 2 = 97.0%), respectively. There is no publication bias in the study.
Conclusions: The Sepsityper kit is a good method for the rapid diagnosis of all kinds of pathogenic microbes. Moreover, it is also very prominent in the identification of Gram-negative bacteria. Keywords : Sepsityper Kit, gram-negative bacteria, gram-positive bacteria, fungi, Sepsis