COVID-19 impacted hospital systems across the globe. Focus shifted to responding to increased healthcare demand while mitigating COVID-19 spread on their campuses. Mitigation efforts limited medical professional-patient interactions, including patient access to preventive cancer screenings. This study tested five hypotheses: H1: Cancer screenings significantly decreased during North Carolina’s (NC) Stay-At-Home (SAH) orders; H2: Cancer diagnoses significantly decreased during NC’s SAH orders; H3: Cancer screenings significantly increased after the end of NC’s SAH orders; H4: Cancer diagnoses significantly increased after the end of NC’s SAH orders; and H5: Advanced cancer diagnoses significantly increased after the end of NC’s stay-at-home orders. Time series regression analysis was employed to quantify trends. Results suggested strong support of H1 and H3, moderate support of H4, mixed support of H5, and no support of H2. Implications of employing robust statistical methods to quantify trends in screenings or diagnoses during periods of health system disruption are discussed.