Background
Effective and applicable predictors of non-alcoholic fatty liver disease (NAFLD) are needed for the non-obese Chinese population. We investigated whether serum gamma-glutamyl transferase (GGT) was associated with incident NAFLD in the non-obese Chinese population.
Methods
This was a retrospective cohort study that enrolled a total of 33153 initially NAFLD-free individuals who underwent a health examination in Wenzhou Medical Center of Wenzhou People’s Hospital from January 2010 to December 2014. We determined the relationship between GGT at enrollment and incident NAFLD during follow-up in 11906 persons. The relationship between GGT levels and incident NAFLD was analyzed using Cox regression and generalized additive models after adjustment for demographic and clinical variables. In addition, we also performed a subgroup analysis, which was explored by Cox proportional hazard models. It was stated that the data had been downloaded from the DATADRYAD website.
Result
Multivariable Cox regression models were used to estimate the hazard ratio (HR) for GGT with incident NAFLD after adjusted demographic and clinical variables. (HR, 1.010; 95% CI, 1.007–1.012; P < 0.001). The incident NAFLD in the highest quartile of GGT levels was 3.653 times as high (95% confidence interval, 2.915 to 4.579) as that in the lowest quartile. A non-linear relationship was firstly detected between GGT and incidence of NAFLD, which had an inflection point of GGT was 26U/L. The effect sizes and the confidence intervals on the left and right sides of the inflection point were 1.104(1.089–1.120)and 1.001༈0.999–1.004༉, respectively. In subgroup analyses, the hazard ratio for incident NAFLD remained consistent across subgroups.
Conclusion
In conclusion, the GGT level in the non-obese Chinese population was statistically significantly associated with incident NAFLD. The relationship between GGT level and incident NAFLD is non-linear. When GGT level is less than 26 U/L, GGT was strong positively with incident NAFLD.