Ethics approval and consent to participate
Every participant provided a written informed consent in accordance with the Declaration of Helsinki. The study protocol was approved by the ethics committee of the University Hospital of St. Anne.
Consent for publication
Not applicable.
Availability of data and materials
The raw data set of this study is available from the corresponding author upon reasonable request. The data are not publicly available due to their sensitive nature to protect the privacy of research participants.
Competing interests
None of the authors has any competing interest to disclose.
Funding
The results of this research have been acquired within CEITEC 2020 (LQ1601) project with financial contribution made by the Ministry of Education, Youths and Sports of the Czech Republic within special support paid from the National Programme for Sustainability II funds.
Acknowledgements
The authors wish to express their sincere thanks to the patients and their families for their support of research activities. We acknowledge the core facility MAFIL of CEITEC supported by the MEYS CR (LM2018129 Czech-BioImaging).
Authors' contributions
Pavel Filip was responsible for the study design, analysis and interpretation of data and preparation of manuscript. Michal Dufek was responsible for study design, patient enrollment and he edited the manuscript. Silvia Mangia, Shalom Michaeli and Martin Bareš participated in the study design and editing of the manuscript. Daniel Schwarz was responsible for the study design, statistical analyses and editing of the manuscript. Lubomír Vojtíšek was responsible for the study design, data acquisition and interpretation and he edited the manuscript.
Authors' information
Affiliations
Pavel Filip1,2,3,4, Michal Dufek2, Silvia Mangia4, Shalom Michaeli4, Martin Bareš2,5, Daniel Schwarz6,7, Lubomír Vojtíšek8*
1 Department of Neurology, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic
2 First Department of Neurology, Faculty of Medicine, Masaryk University and University Hospital of St. Anne, Brno, Czech Republic
3 International Clinical Research Center (ICRC), University Hospital of St. Anne, Brno, Czech Republic
4 Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA
5 Department of Neurology, School of Medicine, University of Minnesota, Minneapolis, USA
6 Masaryk University, Faculty of Medicine, Institute of Biostatistics and Analyses, Brno, Czech Republic
7 Institute of Biostatistics and Analyses, Ltd. (Masaryk University spin-off), Brno, Czech Republic
8 Central European Institute of Technology (CEITEC) Masaryk University, Neuroscience Centre, Brno, Czech Republic
Corresponding Author
Lubomír Vojtíšek
e-mail: [email protected]
phone: +420 604 291 902
postal address: CEITEC, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic