The theoretical finding of the Sanal-flow-choking [PMCID: PMC7267099] and streamtube flow choking (V.R.Sanal Kumar et al., Physics of Fluids, Vol.33, No.3, 2021, DOI: 10.1063/5.0040440) are methodological advancements in predicting the deflagration-to-detonation-transition (DDT) in the real-world-fluid flows (continuum/non-continuum) with credibility.[1,2] Herein, we provide a proof of the concept of the Sanal-flow-choking and streamtube-flow-choking causing DDT in wall-bounded and free-external flows. Once the streamlines compacted, the considerable pressure difference attains inside the streamtube and the flow gets accelerated to the constricted region for satisfying the continuity condition set by the conservation law of nature. If the shape of the streamtube in the internal/external flow is similar to the convergent-divergent (CD) duct the phenomenon of the Sanal-flow-choking and supersonic flow development occurs at a critical-total-to-static pressure ratio (CPR) in yocto to yotta scale systems and beyond, which leads to shock wave generation or detonation as the case may me. At the lower critical detonation or hemorrhage index, the CPR of the reacting flow and the critical blood-pressure-ratio (BPR) of the subjects (human being/animal) are unique functions of the heat-capacity-ratio (HCR) of the evolved gas in the CD duct (V.R.Sanal Kumar et al., Global Challenges, Wiley Publication, January 2021, DOI: 10.1002/gch2.202000076, PMCID: PMC7933821; Sanal Kumar V.R et al. Stroke, Vol. 52, Issue Suppl_11 March 2021, doi.org/10.1161/str.52.suppl_1.P804). In silico results are presented herein to establish the proof of the concept of the Sanal-flow-choking and streamtube-flow-choking causing shock-wave/detonation in diabatic flow systems and asymptomatic-hemorrhagic-stroke in biological systems. The physics of detonation chemistry presented herein sheds light for exploring environmental and supernova explosions.[107] In silico results reported herein provide an authentic answer to many unresolved research questions in Physics in general and aerospace, mechanical, biological, chemical, energy, environmental, nano and material sciences in particular.