Nowadays, the liquid nitrogen cooling in aluminium extrusion is a widely adopted industrial practice to increase the process productivity as well as to improve the extruded profile surface quality by reducing the profile exit temperatures. The cooling channels are commonly designed on the basis of die maker experience only, usually obtaining modest performances in terms of cooling efficiency. Trial-and-error approach is time and cost consuming, thus providing a relevant industrial interest in the development of reliable numerical simulations able to foresee and optimize the nitrogen cooling effect during the die design stage. In this work, an extensive experimental campaign was performed during the extrusion process of an AA6060 industrial hollow profile, in different conditions of nitrogen flow rate and ram speed. The monitored data (die and profile temperatures and extrusion load) were compared with the outputs of a fast and efficient numerical model proposed by the authors, and developed in the COMSOL Multiphysics code, able to compute not only the effect of nitrogen liquid flow but also the gaseous condition. The results of the simulations showed a good agreement with experimental data and evidenced how far was the experimental cooling channel design from an optimized condition.