1. O'Neill, L. A., Kishton, R. J., & Rathmell, J. (2016). A guide to immunometabolism for immunologists. Nature Reviews Immunology, 16(9), 553.
2. Wang, A., Luan, H. H., & Medzhitov, R. (2019). An evolutionary perspective on immunometabolism. Science, 363(6423).
3. Van den Bossche, J., O’Neill, L. A., & Menon, D. (2017). Macrophage immunometabolism: where are we (going)?. Trends in immunology, 38(6), 395-406.
4. Russell, D. G., Huang, L., & VanderVen, B. C. (2019). Immunometabolism at the interface between macrophages and pathogens. Nature Reviews Immunology, 19(5), 291-304.
5. Ryan, D. G., & O'Neill, L. A. (2020). Krebs cycle reborn in macrophage immunometabolism. Annual review of immunology, 38, 289-313.
6. Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., ... & O’Neill, L. A. J. (2013). Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature, 496(7444), 238-242.
7. Mills, E. L., Kelly, B., Logan, A., Costa, A. S., Varma, M., Bryant, C. E., ... & O’Neill, L. A. (2016). Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages. Cell, 167(2), 457-470.
8. Bricker, D. K., Taylor, E. B., Schell, J. C., Orsak, T., Boutron, A., Chen, Y. C., ... & Rutter, J. (2012). A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science, 337(6090), 96-100.
9. Herzig, S., Raemy, E., Montessuit, S., Veuthey, J. L., Zamboni, N., Westermann, B., ... & Martinou, J. C. (2012). Identification and functional expression of the mitochondrial pyruvate carrier. Science, 337(6090), 93-96.
10. Lauterbach, M. A., Hanke, J. E., Serefidou, M., Mangan, M. S., Kolbe, C. C., Hess, T., ... & Latz, E. (2019). Toll-like receptor signaling rewires macrophage metabolism and promotes histone acetylation via ATP-citrate lyase. Immunity, 51(6), 997-1011.
11. Langston, P. K., Nambu, A., Jung, J., Shibata, M., Aksoylar, H. I., Lei, J., ... & Horng, T. (2019). Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses. Nature immunology, 20(9), 1186-1195.
12. Meiser, J., Krämer, L., Sapcariu, S. C., Battello, N., Ghelfi, J., D'Herouel, A. F., ... & Hiller, K. (2016). Pro-inflammatory macrophages sustain pyruvate oxidation through pyruvate dehydrogenase for the synthesis of itaconate and to enable cytokine expression. Journal of Biological Chemistry, 291(8), 3932-3946.
13. Bae, S., Park, P. S. U., Lee, Y., Mun, S. H., Giannopoulou, E., Fujii, T., ... & Park-Min, K. H. (2021). MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages. Cell Reports, 35(11), 109264.
14. McCommis, K. S., Chen, Z., Fu, X., McDonald, W. G., Colca, J. R., Kletzien, R. F., ... & Finck, B. N. (2015). Loss of mitochondrial pyruvate carrier 2 in the liver leads to defects in gluconeogenesis and compensation via pyruvate-alanine cycling. Cell metabolism, 22(4), 682-694.
15. Divakaruni, A. S., Paradyse, A., Ferrick, D. A., Murphy, A. N., & Jastroch, M. (2014). Analysis and interpretation of microplate-based oxygen consumption and pH data. Methods in enzymology, 547, 309-354.16. Vigueira, P. A., McCommis, K. S., Schweitzer, G. G., Remedi, M. S., Chambers, K. T., Fu, X., ... & Finck, B. N. (2014). Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion. Cell reports, 7(6), 2042-2053.
17. Divakaruni, A. S., Wiley, S. E., Rogers, G. W., Andreyev, A. Y., Petrosyan, S., Loviscach, M., ... & Murphy, A. N. (2013). Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proceedings of the national academy of sciences, 110(14), 5422-5427.
18. Divakaruni, A. S., Hsieh, W. Y., Minarrieta, L., Duong, T. N., Kim, K. K., Desousa, B. R., ... & Murphy, A. N. (2018). Etomoxir inhibits macrophage polarization by disrupting CoA homeostasis. Cell metabolism, 28(3), 490-503.
19. Martínez-Reyes, I., Diebold, L. P., Kong, H., Schieber, M., Huang, H., Hensley, C. T., ... & Chandel, N. S. (2016). TCA cycle and mitochondrial membrane potential are necessary for diverse biological functions. Molecular cell, 61(2), 199-209.
20. Hill, B. G., Benavides, G. A., Lancaster, J. R., Ballinger, S., Dell’Italia, L., Zhang, J., & Darley-Usmar, V. M. (2012). Integration of cellular bioenergetics with mitochondrial quality control and autophagy. Biological chemistry, 393(12), 1485-1512.
21. Chua, Y. L., Dufour, E., Dassa, E. P., Rustin, P., Jacobs, H. T., Taylor, C. T., & Hagen, T. (2010). Stabilization of hypoxia-inducible factor-1α protein in hypoxia occurs independently of mitochondrial reactive oxygen species production. Journal of Biological Chemistry, 285(41), 31277-31284.
22. Agani, F. H., Pichiule, P., Chavez, J. C., & LaManna, J. C. (2002). Inhibitors of mitochondrial complex I attenuate the accumulation of hypoxia-inducible factor-1 during hypoxia in Hep3B cells. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 132(1), 107-109.
23. Cramer, T., Yamanishi, Y., Clausen, B. E., Förster, I., Pawlinski, R., Mackman, N., ... & Johnson, R. S. (2003). HIF-1α is essential for myeloid cell-mediated inflammation. Cell, 112(5), 645-657.
24. Ke, Q., & Costa, M. (2006). Hypoxia-inducible factor-1 (HIF-1). Molecular pharmacology, 70(5), 1469-1480.
25. Baardman, J., Verberk, S. G., van der Velden, S., Gijbels, M. J., van Roomen, C. P., Sluimer, J. C., ... & Van den Bossche, J. (2020). Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques. Nature communications, 11(1), 1-15.
26. Wang, Y., Tang, B., Long, L., Luo, P., Xiang, W., Li, X., ... & Shi, C. (2021). Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages. Nature communications, 12(1), 1-16.
27. Liu, X., Cooper, D. E., Cluntun, A. A., Warmoes, M. O., Zhao, S., Reid, M. A., ... & Locasale, J. W. (2018). Acetate production from glucose and coupling to mitochondrial metabolism in mammals. Cell, 175(2), 502-513.
28. Bensard, C. L., Wisidagama, D. R., Olson, K. A., Berg, J. A., Krah, N. M., Schell, J. C., ... & Rutter, J. (2020). Regulation of tumor initiation by the mitochondrial pyruvate carrier. Cell metabolism, 31(2), 284-300.
29. Vacanti, N. M., Divakaruni, A. S., Green, C. R., Parker, S. J., Henry, R. R., Ciaraldi, T. P., ... & Metallo, C. M. (2014). Regulation of substrate utilization by the mitochondrial pyruvate carrier. Molecular cell, 56(3), 425-435.
30. Bender, T., Pena, G., & Martinou, J. C. (2015). Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes. The EMBO journal, 34(7), 911-924.
31. Schell, J. C., & Rutter, J. (2013). The long and winding road to the mitochondrial pyruvate carrier. Cancer & metabolism, 1(1), 1-9.
32. Proudlove, M. O., Beechey, R. B., & Moore, A. L. (1987). Pyruvate transport by thermogenic-tissue mitochondria. Biochemical Journal, 247(2), 441-447.
33. Halestrap, A. P. (1975). The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors. Biochemical Journal, 148(1), 85-96.
34. Zhang, X., Goncalves, R., & Mosser, D. M. (2008). The isolation and characterization of murine macrophages. Current protocols in immunology, 83(1), 14-1.
35. Wang, F., Zhang, S., Jeon, R., Vuckovic, I., Jiang, X., Lerman, A., ... & Herrmann, J. (2018). Interferon gamma induces reversible metabolic reprogramming of M1 macrophages to sustain cell viability and pro-inflammatory activity. EBioMedicine, 30, 303-316.
36. Wang, F., Zhang, S., Vuckovic, I., Jeon, R., Lerman, A., Folmes, C. D., ... & Herrmann, J. (2018). Glycolytic stimulation is not a requirement for M2 macrophage differentiation. Cell metabolism, 28(3), 463-475.
37. Lee WN, Byerley LO, Bergner EA, Edmond J. (1991). Mass isotopomer analysis: theoretical and practical considerations. Biol Mass Spectrom. 20, 451-8.