Table 1. Basic characteristics between axSpA patients and healthy controls
|
Control group (n=71)
|
axSpA group(n=205)
|
P value
|
Age(years)
|
31.00(29.00,35.00)
|
30.00(25.00,36.00)
|
0.076
0.063
|
Sex(male/female)
|
52/19
|
35/170
|
0.063
|
TC (mmol/L)
|
4.79(4.30,5.32)
|
3.99(3.57,4.64)
|
<0.001
|
TG (mmol/L
|
1.14(0.88,1.53)
|
0.86(0.62,1.20)
|
<0.001
|
LDL-c(mmol/L)
|
2.71(2.07,3.11)
|
2.38(1.96,2.94)
|
0.027
|
HDL-c(mmol/L)
|
1.23(1.10,1.42)
|
1.03(0.90,1.20)
|
<0.001
|
TC/HDL-c
|
3.89(3.26,4.25)
|
4.01(3.55,4.46)
|
0.132
|
TG/HDL-c
|
0.94(0.72,1.21)
|
0.85(0.61,1.17)
|
0.154
|
LDL-c/HDL-c
|
2.13±0.62
|
2.35±0.74
|
0.022
|
BASDAI
|
-
|
4.80(4.40,5.70)
|
|
BASFI
|
-
|
2.20(0.80,3.40)
|
|
TC, total cholesterol; TG, triglycerides; HDL-c, high-density lipoprotein cholesterol; TC/HDL-c, total cholesterol-high-density lipoprotein cholesterol ratio; TG/HDL-c, triglycerides-high-density lipoprotein cholesterol ratio; LDL-c/HDL-c, low-density lipoprotein cholesterol-high-density lipoprotein cholesterol ratio; BASDAI, Bath Ankylosing Spondylitis Disease Activity Index; BASFI, Bath Ankylosing Spondylitis Functional Index
Table 2. The diagnostic value of serum lipid parameters for axSpA using ROC cures
|
AUC (CI95%)
|
P value
|
Optimal cut off value
|
Youden index
|
Sensitivity
|
Specificity
|
TC (mmol/L)
TG (mmol/L)
LDL-c(mmol/L)
|
0.728(0.662-0.793)
0.668(0.599-0.737)
0.588(0.509-0.667)
|
<0.001
<0.001
0.027
|
4.200
0.960
2.700
|
0.403
0.303
0.214
|
80.3%
58.5%
50.7%
|
60.0%
71.8%
70.7%
|
HDL-c(mmol/L)
|
0.752(0.693-0.811)
|
<0.001
|
1.075
|
0.432
|
62.9%
|
80.3%
|
TC/HDL-c
TG/HDL-c
|
0.560(0.484-0.636)
0.557(0.481-0.633)
|
0.132
0.154
|
4.268
0.885
|
0.136
0.152
|
36.1%
62.0%
|
77.5%
53.2%
|
LDL-c/HDL-c
|
0.607(0.534-0.681)
|
0.007
|
2.528
|
0.183
|
38.0%
|
80.3%
|
TC, total cholesterol; TG, triglycerides; HDL-c, high-density lipoprotein cholesterol; TC/HDL-c, total cholesterol-high-density lipoprotein cholesterol ratio; TG/HDL-c, triglycerides-high-density lipoprotein cholesterol ratio; LDL-c/HDL-c, low-density lipoprotein cholesterol-high-density lipoprotein cholesterol ratio
Table 3. Associations of serum lipid parameters with disease activity indexes in axSpA patients.
|
BASDAI
|
BASFI
|
CRP
|
ESR
|
|
r
|
P value
|
r
|
P value
|
r
|
P value
|
r
|
P value
|
TC (mmo/L)
|
-0.014
|
0.842
|
-0.005
|
0.942
|
-0.227
|
<0.001
|
-0.148
|
0.020
|
TG (mmol/L)
|
-0.014
|
0.839
|
0.030
|
0.686
|
-0.171
|
0.007
|
-0.217
|
0.001
|
LDL-c(mmol/L)
|
0.018
|
0.797
|
0.006
|
0.941
|
-0.030
|
0.639
|
-0.012
|
0.857
|
HDL-c(mmol/L)
|
-0.153
|
0.029
|
-0.146
|
0.051
|
-0.423
|
<0.001
|
-0.307
|
<0.001
|
TC/HDL-c
|
0.179
|
0.010
|
0.149
|
0.047
|
0.194
|
0.002
|
0.185
|
0.004
|
TG/HDL-c
|
0.065
|
0.352
|
0.088
|
0.242
|
0.009
|
0.885
|
-0.079
|
0.215
|
LDL-c/HDL-c
|
0.144
|
0.040
|
0.093
|
0.216
|
0.225
|
<0.001
|
0.209
|
0.001
|
CRP (mg/L)
|
0.257
|
<0.001
|
0.310
|
<0.001
|
-
|
-
|
0.746
|
<0.001
|
ESR (mm/h)
|
0.257
|
<0.001
|
0.296
|
<0.001
|
0.746
|
<0.001
|
-
|
-
|
TC, total cholesterol; TG, triglycerides; HDL-c, high-density lipoprotein cholesterol; TC/HDL-c, total cholesterol-high-density lipoprotein cholesterol ratio; TG/HDL-c, triglycerides-high-density lipoprotein cholesterol ratio; LDL-c/HDL-c, low-density lipoprotein cholesterol-high-density lipoprotein cholesterol ratio; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; BASDAI, Bath Ankylosing Spondylitis Disease Activity Index; BASFI, Bath Ankylosing Spondylitis Functional Index
Table 4. Comparison of serum lipid parameters between axSpA of active group and remission group
|
Remission axSpA (n=122)
|
Active axSpA(n=83)
|
P value
|
Age(years)
|
29.50(24.00,35.00)
|
30.00(25.00,37.00)
|
0.350
|
Sex(male/female)
|
103/19
|
67/16
|
0.489
|
TC (mmol/L)
|
3.98(3.53,4.66)
|
4.00(3.58,4.61)
|
0.853
|
TG (mmol/L)
|
0.88(0.61,1.24)
|
0.80(0.63,1.18)
|
0.752
|
LDL-c(mmol/L)
|
2.39(1.90,2.96)
|
2.37(2.03,2.82)
|
0.601
|
HDL-c(mmol/L)
|
1.04(0.93,1.22)
|
0.99(0.86,1.17)
|
0.042
|
TC/HDL-c
|
3.84±0.92
|
4.20±0.75
|
0.003
|
TG/HDL-c
|
0.86(0.58,1.17)
|
0.84(0.66,1.18)
|
0.487
|
LDL-c/HDL-c
|
2.25±0.76
|
2.51±0.68
|
0.011
|
CRP (mg/L)
|
7.83(3.14,23.50)
|
18.30(6.55,32.25)
|
0.001
|
ESR (mm/L)
|
20.00(10.00,40.00)
|
31.00(16.50,50.00)
|
0.006
|
BASDAI
|
2.00(1.00,3.00)
|
4.80(4.40,5.70)
|
<0.001
|
BASFI
|
0.30(0.00,1.50)
|
2.20(0.80,3.40)
|
<0.001
|
TC, total cholesterol; TG, triglycerides; HDL-c, high-density lipoprotein cholesterol; TC/HDL-c, total cholesterol-high-density lipoprotein cholesterol ratio; TG/HDL-c, triglycerides-high-density lipoprotein cholesterol ratio; LDL-c/HDL-c, low-density lipoprotein cholesterol-high-density lipoprotein cholesterol ratio; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; BASDAI, Bath Ankylosing Spondylitis Disease Activity Index; BASFI, Bath Ankylosing Spondylitis Functional Index
Table 5. The diagnostic value of serum lipid parameters, CRP and ESR for axSpA of active group using ROC cures
Parameters
|
AUC(CI95%)
|
P value
|
Optimal cut off value
|
Youden index
|
Sensitivity
|
Specificity
|
TC (mmol/L)
TG (mmol/L)
LDL-c(mmol/L)
|
0.616(0.539,0.694)
0.513(0.432-0.594)
0.522(0.441-0.602)
|
0.005
0.752
0.601
|
5.70
0.795
1.805
|
0.071
0.101
0.084
|
9.60%
49.4%
90.4%
|
97.5%
60.7%
18.0%
|
HDL-c(mmol/L)
|
0.584(0.503-0.664)
|
0.420
|
0.955
|
0.162
|
48.2%
|
68.0%
|
TC/HDL-c
TG/HDL-c
|
0.616(0.539-0.694)
0.529(0.449-0.608)
|
0.005
0.487
|
4.218
0.528
|
0.195
0.117
|
50.6%
90.4%
|
68.9%
21.3%
|
LDL-c/HDL-c
|
0.600(0.523-0.678)
|
0.015
|
2.371
|
0.192
|
60.2%
|
59.0%
|
CRP
|
0.632(0.554-0.710)
|
0.001
|
11.000
|
0.285
|
71.1%
|
57.4%
|
ESR
|
0.614(0.537,0.690)
|
0.006
|
14.500
|
0.236
|
84.3%
|
39.3%
|
TC, total cholesterol; TG, triglycerides; HDL-c, high-density lipoprotein cholesterol; TC/HDL-c, total cholesterol-high-density lipoprotein cholesterol ratio; TG/HDL-c, triglycerides-high-density lipoprotein cholesterol ratio; LDL-c/HDL-c, low-density lipoprotein cholesterol-high-density lipoprotein cholesterol ratio; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein
Table 6. Logistic regression analysis of independent indicator for axSpA disease activity
Risk factor
|
OR(CI95%)
|
P value
|
TC
|
-
|
0.991
|
TG
|
-
|
0.821
|
LDL-c
|
-
|
0.557
|
HDL-c
|
-
|
0.587
|
TC/HDL-
|
1.626(1.128-2.343)
|
0.009
|
TG/HDL-c
|
-
|
0.672
|
LDL-C/HDL-c
|
-
|
0.599
|
CRP
|
1.019(1.003-1.035)
|
0.019
|
ESR
|
-
|
0.637
|
TC, total cholesterol; TG, triglycerides; HDL-c, high-density lipoprotein cholesterol; TC/HDL-c, total cholesterol-high-density lipoprotein cholesterol ratio; TG/HDL-c, triglycerides-high-density lipoprotein cholesterol ratio; LDL-c/HDL-c, low-density lipoprotein cholesterol-high-density lipoprotein cholesterol ratio; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; BASDAI, Bath Ankylosing Spondylitis Disease Activity Index; BASFI, Bath Ankylosing Spondylitis Functional Index