Consumption of inorganic Arsenic (iAs) beyond safe levels leads to many diseases including cancers of skin. Carcinogenicity of iAs is mediated through the generation of excessive reactive oxygen species. Previous studies have shown that molecules present in black tea extract (BTE) can ameliorate many deleterious effects of iAs on genetic pathways. This study examines whether BTE can reduce deleterious epigenetic effects due to iAs in Swiss albino mice. We used three groups of mice, a control group, a group that was administered iAs and a group that was administered iAs and BTE. Invasive squamous cell carcinoma (SCC) developed in the iAs group after 330 days, but mice in the iAs+BTE group developed only hyperplasic and dysplastic changes. We report on expression levels of several histone methylation and acetylation marks, as well as those of several histone methylases, demethylases and acetylases. Several aberrant expression levels due to iAs were modulated by BTE. However, the expression level of JARID1B, a histone demethylase and a key marker of SCC was not modulated by BTE, though its demethylation activity was reduced by BTE. in silico studies using docking and molecular dynamical simulation showed that theaflavin compounds present in BTE are excellent inhibitors of JARID1B.