Skin wound healing is a complex process involving three phases: inflammation, cell proliferation, and tissue remodeling. The healing process is regulated by various cytokines, chemokines, and growth factors. Recently, a new polyamine has gained attention for its effects on wound healing. Spermidine is a naturally occurring compound that is present in cheese, corn, mushrooms, legumes, soya products, and whole grains. Following up on a previous study that reported that SPD may promote wound healing, researchers investigated its effects on skin wound repair. Using a mouse model, they found that both oral and topical administration of SPD significantly accelerated skin wound healing. SPD boosted signaling through the urokinase-type plasminogen activator (uPA) signaling pathway and enhanced the expression of the pro-inflammatory cytokines IL-6 and TNF-α in wound sites. In vitro scratch and cell proliferation assays also indicated that SPD administration accelerated wound closure and cell proliferation. Although further studies are needed to expand the study beyond mice, these results indicate that SPD administration may contribute to the development of new, effective treatments to accelerate skin wound healing.