Research Article
Design, Synthesis, And Evaluation of Functionalized Diamino-butylbenzamides As Selective Dopamine D3 Receptor Ligands
https://doi.org/10.21203/rs.3.rs-969699/v1
This work is licensed under a CC BY 4.0 License
You are reading this latest preprint version
Substance use disorder remains a major, unmet medical need. Cocaine is one of the most commonly abused recreational drugs and in 2018, there were over 5.5 million current cocaine users. There are no approved therapies for the treatment of cocaine use disorder, but the D3 dopamine receptor has been identified as a potential therapeutic target. We have identified a series of functionalized diamino-butylbenzamides that are potent D3 binders with moderate to high selectivity for D3 over D2.
Dopamine
D3 dopamine receptor
D2 dopamine receptor
substance use disorder
cocaine
Editorial decision: Major Revision
26 Oct, 2021
Reviewers invited by journal
20 Oct, 2021
Reviews received at journal
15 Oct, 2021
Editor assigned by journal
13 Oct, 2021
First submitted to journal
11 Oct, 2021
You are reading this latest preprint version