Ethics approval and consent to participate
Collection and use of patient samples were approved by the Institutional Review Board of the University of Texas MD Anderson Cancer Center.
Consent for publication
Not applicable
Availability of data and material
Data is available upon request.
Competing interests
L.A.B. serves on advisory committees for AstraZeneca, AbbVie, GenMab, BergenBio, Pharma Mar SA, Sierra Oncology, Merck, Bristol Myers Squibb, Genentech, and Pfizer and has research support from AbbVie, AstraZeneca, GenMab, Sierra Oncology and Tolero Pharmaceuticals. I.W. reports grants and personal fees from Genentech/Roche, Bayer, Bristol-Myers Squibb, AstraZeneca/Medimmune, Pfizer, HTG Molecular, Merck, and Guardant Health; personal fees from GlaxoSmithKline and MSD; grants from Oncoplex, DepArray, Adaptive, Adaptimmune, EMD Serono, Takeda, Amgen, Karus, Johnson & Johnson, Iovance, 4D, Novartis, Oncocyte and Akoya. J.J.Z. reports research funding from Merck, Johnson and Johnson, and consultant fees from BMS, Johnson and Johnson, AstraZeneca, Geneplus, OrigMed and Innovent outside the submitted work. J.V.H. reports honorariums from AstraZeneca, Boehringer-Ingelheim, Catalyst, Genentech, GlaxoSmithKline, Guardant Health, Foundation medicine, Hengrui Therapeutics, Eli Lilly, Novartis, Spectrum, EMD Serono, Sanofi, Takeda, Mirati Therapeutics, BMS, BrightPath Biotherapeutics, Janssen Global Services, Nexus Health Systems, EMD Serono, Pneuma Respiratory, Kairos Venture Investments, Roche and Leads Biolabs. A.R. serves on the Scientific Advisory Board and has received honoraria from Adaptive Biotechnologies. The other authors declare no competing interests.
Funding
This work was supported by Conquer Cancer Foundation ASCO Young Investigator Award, MD Anderson Physician Scientist Award, Cancer Prevention & Research Institute of Texas (CPRIT) Multiple Investigator Award, TJ Martell Foundation, NIH/NCI R01-CA207295, NIH/NCI U01-CA213273 and Department of Defense (LC170171). A.R. is supported by the Exon 20 Group, Rexanna’s Foundation for Fighting Lung Cancer, the Waun Ki Hong Lung Cancer Research Fund, MD Anderson’s Lung Cancer Moon Shot and the University Cancer Foundation via the Institutional Research Grant program at the University of Texas MD Anderson Cancer Center.
Authors' contributions
A.R., D.L.G., L.A.B. and J.J.Z. conceived the study. J.L. and R.C. led the data analysis. J.F, D.T., and C.W.C. led the pathological assessment, multi-region sample preparation and DNA extraction. R.C., K.Q. and M.T. collected resected specimens and clinical data. L.L. and C.G. performed DNA preparation and whole-exome sequencing. X.S. and J.H.Z. performed sequencing raw data processing. J.L., X.H., K.Q., M.T. and A.M. performed downstream bioinformatics analyses. R.C., C.B, P.J., J.V.H., I.W., P.A.F., D.L.G, L.A.B., J.J.Z. and A.R. interpreted the data for clinical and pathological correlation. R.C. and J.L. performed statistical analyses. R.C., J.J.Z and A.R. wrote the paper. All authors edited the manuscript.
Acknowledgements
Not applicable
Authors' information
Authors: Runzhe Chen1,2,#, Jun Li2,#, Junya Fujimoto3, Xin Hu2, Kelly Quek1, Ming Tang2, Akash Mitra2, Carmen Behrens1, Chi-Wan Chow3, Peixin Jiang1, Latasha D. Little2, Curtis Gumbs2, Xingzhi Song2, Jianhua Zhang2, Dongfeng Tan4, John V. Heymach1, Ignacio Wistuba3, P. Andrew Futreal2, Don L. Gibbons1,*, Lauren A. Byers1,*, Jianjun Zhang1,2*, Alexandre Reuben1,*
Affiliations:
1Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
2Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
3Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
4Department of Pathology, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
# co-first authors
*Correspondence: [email protected] (D.L.G.), [email protected] (L.A.B.), [email protected] (J.J.Z.), [email protected] (A.R.)